Aims: Unbalance between coagulation and fibrinolysis systems and their regulatory mechanisms may cause bleeding and formation of coagulate. There are conflict reports about the effect of regulated physical activities on these systems. The aim of this study was to evaluate the effect of resistant exercise on coagulation and fibrinolysis factors in inactive aged men.

Methods: This experimental study was done in all inactive healthy men of Saghez city, Iran which were between 60 to 70 years old. 16 studied samples that were selected by easy accessible sampling method were randomly divided into 2 resistance and control groups. Resistance group performed 12 sessions of exercises in 4 weeks and control group did no exercises in this period. Each session of exercise included 6 movements in 3 rounds (8 repeats during each round). The levels of fibrinogen, PT, PTT, D-dimer and platelets counts were measured before and after exercise period. Data was analyzed by using SPSS 16 software and dependent and independent T tests.

Results: Resistant training induced significant decrease in fibrinogen, PTT, PT and platelets counts ( p<0.05 ) and significant increase in D-dimer ( p<0.05 ). These changes were not traced in the control group ( p>0.05 ).

Conclusion: Medium level of resistant training lead to decrease of coagulation factors, PT, PTT and platelets counts and increase of D-dimer fibrinolysis factor that can prevent vascular thrombosis.