Volume 11, Issue 4 (vol- 4 2006)                   Intern Med Today 2006, 11(4): 24-29 | Back to browse issues page

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Abstract:   (79496 Views)
Background & Aim: The most common Hypochromic microcytic Anemia is Iron deficiency(IDA) and _thalaseemia trait.These are common in Iran and their diagnosis and distinction are important particularly in marriage consults. The results of some studies have shown that IDA can cause misdiagnosis of heterstygote b_thalassemia due to decrease in HbA2 level. Our aim of study is evaluation of effect of IDA on HbA2 levels. Furthermore hematologic values in CBC of these two disease are compared. Materials & methods: In this prospective study, 291 patients including Normal control group, heterozygote  and b thalassemia, IDA and coexistence of IDA and B_thalassemia were evaluated for laboratory tests, including CBC, serum ferritin, Iron, TIBC and Alkaline hemoglobin clectrophoresis. Then data of patients on the basis of diagnostic criteria was accumulated in different groups and Analyzed with use of SPSS soft ware and analytical Tests. Results: HbA2 level in normal groups and IDA were %2.9±0.4 and 2.7%±0.6 respectively. in _thalaseemia trait HbA2 was %5.6± 0.9 and in coexistence of _thalassemia and IDA was %4.7±0.1. There was a significant difference between HbA2 level in b-thalassemia and Normal Control groups and between b_thalaseemia and coexistence of b_thalaseemia and IDA.There was significant increase in RBC counts, Hb, Hct and MCHC values in b_thalaseemia trait in comparison to IDA, but there was not significant difference in MCV between these. RDW was elevated in two diseases but it was more significant in IDA. Conclusion: IDA can cause a decrease in HbA2 level. This Particularly in cases with coexistance of IDA and -thalassemia trait can cause misdiagnosis. Therefore in suspicious cases of -thalassemia trait in IDA background, It is better to do hemoglobin electrophoresis after treatment of IDA.
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Type of Study: Original | Subject: Internal Medicine
Received: 2008/05/24 | Published: 2006/01/15

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