Volume 20, Issue 4 (1-2015)                   Intern Med Today 2015, 20(4): 231-236 | Back to browse issues page

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Taheri Chadorneshin H., Afzalpour M.E., Abtahi H., Foadoddini M.. Effect of Intense Exercise Training on Hydrogen Peroxide, Tumor Necrosis Factor-Alpha and the Selected Neurotrophins in Rat’s Brain. Intern Med Today 2015; 20 (4) :231-236
URL: http://imtj.gmu.ac.ir/article-1-2078-en.html
1- Exercise Physiology Department, Education and Sport Sciences Faculty, Birjand University, Birjand, Iran , kh.taheri_62@yahoo.com
2- Exercise Physiology Department, Education and Sport Sciences Faculty, Birjand University, Birjand, Iran
3- Clinical Biochemistry Department, Basic Sciences Faculty, Gonabad University of Medical Sciences, Gonabad, Iran
4- Atherosclerosis & Coronary Research Center, Birjand University of Medical Sciences, Birjand, Iran
Abstract:   (5640 Views)
Aims: Alpha tumor necrosis factor and Hydrogen peroxide increase in neurotrophins expression in several brain structures. The purpose of this study was to investigate the interactive effect of Hydrogen peroxide and neurotrophic tumor necrosis factor with brain-derived neurotrophic factor by glial cell-derived neurotrophic factor after severe exercise. Materials & Methods: This experimental study was done on 16 adult Wistar albino rats 280g and 3months old. Animals were divided into two intense exercise and sedentary control groups. Animals ran for 6 weeks, 6 days a week, at the speed of 27m per minute and on treadmill for 60 minutes daily. Using kit, the content of BDNF, GDNF, and TNF-α were measured using sandwich ELISA and hydrogen peroxide levels was analyzed by colorimetric assay. Data analyzed by SPSS 16 and Independent-T test. Findings: Hydrogen peroxide levels in the brain, in intense exercise group increased significantly compared with control group (p= 0.006). TNF-α, GDNF and BDNF Levels in the brain in intense exercise group significantly increased compared with control group (p=0.001). Conclusion: Intense running on treadmill increase BDNF and GDNF content in brain of albino Wistar rats through increasing the H2O2 and TNF-α levels.
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Type of Study: Original | Subject: Physiology
Received: 2014/10/26 | Accepted: 2015/01/6 | Published: 2015/01/7

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