Volume 27, Issue 2 (Spring 2021)
Intern Med Today 2021, 27(2): 130-147 |
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1- Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
2- Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran. , alireza54.barari@gmail.com
3- Department of Sport Physiology, Sari Branch, Islamic Azad University, Sari, Iran.
2- Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran. , alireza54.barari@gmail.com
3- Department of Sport Physiology, Sari Branch, Islamic Azad University, Sari, Iran.
Abstract: (2143 Views)
Aims: A high-fat diet, smoking, and a sedentary lifestyle are the major causes of Coronary Artery Disease (CAD). This study aimed to explore the effect of interval training and the consumption of fenugreek seed extract on FGF-21 and VEGF gene expression among patients with CAD.
Methods & Materials: The present quasi-experimental study was conducted on a sample of 32 male patients with CAD, aged between 55 and 65 years. They were randomly divided into four groups: control, training only, fenugreek only, and training + fenugreek. The training program consisted of eight weeks of interval running, three sessions per week with an intensity of 55% and 65% of heart rate reserve, with a gradually increasing intensity. Subjects consumed 10 mg/kg of fenugreek extract daily. Real-time PCR was used to measure the expression of FGF-21 and VEGF genes.
Findings: The results showed that the mean expression ratios of FGF-21 in training only, fenugreek only, and training + fenugreek groups were significantly higher than the control group (P<0.0001). The fenugreek + training group had a greater significant increase (P<0.0001) more than the training + fenugreek group. Moreover, the mean Coefficient of Variation (CV) of VEGF gene expression was significantly increased more than that in the training group (P<0.0001), fenugreek group (P=0.0004), and the training + fenugreek group (P<0.0001), compared to the control group. The fenugreek + training group had a greater and more significant increase than the training only (P=0.0181) and the fenugreek only groups (P<0.0495).
Conclusion: The results showed that a combination of interval training and consumption of fenugreek seed extract increased the CV of FGF-21 and VEGF gene expression and thus, have beneficial effects on the angiogenesis pathway in patients with CADs.
Methods & Materials: The present quasi-experimental study was conducted on a sample of 32 male patients with CAD, aged between 55 and 65 years. They were randomly divided into four groups: control, training only, fenugreek only, and training + fenugreek. The training program consisted of eight weeks of interval running, three sessions per week with an intensity of 55% and 65% of heart rate reserve, with a gradually increasing intensity. Subjects consumed 10 mg/kg of fenugreek extract daily. Real-time PCR was used to measure the expression of FGF-21 and VEGF genes.
Findings: The results showed that the mean expression ratios of FGF-21 in training only, fenugreek only, and training + fenugreek groups were significantly higher than the control group (P<0.0001). The fenugreek + training group had a greater significant increase (P<0.0001) more than the training + fenugreek group. Moreover, the mean Coefficient of Variation (CV) of VEGF gene expression was significantly increased more than that in the training group (P<0.0001), fenugreek group (P=0.0004), and the training + fenugreek group (P<0.0001), compared to the control group. The fenugreek + training group had a greater and more significant increase than the training only (P=0.0181) and the fenugreek only groups (P<0.0495).
Conclusion: The results showed that a combination of interval training and consumption of fenugreek seed extract increased the CV of FGF-21 and VEGF gene expression and thus, have beneficial effects on the angiogenesis pathway in patients with CADs.
Keywords: Interval training, Fenugreek, Fibroblast Growth Factor (FGF21), Vascular Endothelial Growth Factor (VEGF), Coronary artery disease
Type of Study: Original |
Subject:
Diseases
Received: 2020/09/16 | Accepted: 2020/10/31 | Published: 2021/04/1
Received: 2020/09/16 | Accepted: 2020/10/31 | Published: 2021/04/1
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