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Volume 28, Issue 1 (Winter 2021)                   Intern Med Today 2021, 28(1): 128-139 | Back to browse issues page


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Delavarian Z, Hashemi S I, Vazifeh Mostaan L, Mozaffari Jovin S, Biabani A, Ghazi A. Comparing the Salivary Zinc Finger Protein 510 Concentration in Patients With Oral Squamous Cell Carcinoma and Healthy Individuals. Intern Med Today 2021; 28 (1) :128-139
URL: http://imtj.gmu.ac.ir/article-1-3600-en.html
1- Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
2- Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3- Department of ORL-Head & Neck Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4- Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5- Dentist, Mashhad, Iran.
6- Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. , ghazial@mums.ac.ir
Abstract:   (1960 Views)
Aims: Oral Squamous Cell Carcinoma (OSCC) is the most frequent malignancy of oral cavity. Early diagnosis of OSCC can provide early treatment and increase the survival rate. Recently, the level of salivary biomarkers has been studied for the early diagnosis of different cancers. This study aims to assess the Zinc Finger protein 510 (ZNF510) concentration, a novel biomarker for the diagnosis of OSCC in early stages, in salvia of patients with OSCC and healthy individuals as 
Methods & Materials: In this study conducted in 2019, 21 OSCC patients and 21 healthy individuals participated and their unstimulated saliva were collected by the spitting method. The ZNF510 concentration was determined using the ELISA technique. All statitical analyses were performed in SPSS software, version 23. The significance level was set at 0.05 for all tests.
Findings: The mean of ZNF510 protein was significantly higher in OSCC patients than in healthy subjects (P=0.019), but after considering age as a confounder variable, the difference was not significant (P=0.090). Moreover, in patients with OSCC, the mean of ZNF510 in those with grade II lesion was significantly higher than in those with lesion grade I (P=0.001). 
Conclusion: Age has an effect on the ZNF510 concentration in saliva. Therefore, further studies by consideration of age factor and using larger sample sizes are recommended.
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Type of Study: Original | Subject: Basic Medical Science
Received: 2020/10/21 | Accepted: 2021/12/25 | Published: 2021/12/31

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