Volume 31, Issue 2 (Spring 2025)
Intern Med Today 2025, 31(2): 0-0 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Zafarmand O, Saremi A. Evaluation of Adiponectin-1 and Glycemic Indices Following Aerobic Exercise in Adults with and without Chronic Diseases: A Systematic Review and Meta-Analysis. Intern Med Today 2025; 31 (2)
URL: http://imtj.gmu.ac.ir/article-1-4123-en.html
URL: http://imtj.gmu.ac.ir/article-1-4123-en.html
1- M.Sc. in Exercise Physiology, Department of Physical Education and Sports Sciences, School of Humanities, University of Yasouj, Yasouj, Iran.
2- Department of Exercise Physiology, Faculty of Sport Sciences, Arak University, Arak, Iran. ,a-saremi@araku.ac.ir
2- Department of Exercise Physiology, Faculty of Sport Sciences, Arak University, Arak, Iran. ,
Abstract: (5 Views)
Introduction: Metabolic disorders and reduced insulin sensitivity are considered key factors in the development of chronic diseases in adults. Adiponectin-1, as a marker of metabolic status, may be influenced by aerobic exercise. This meta-analysis aimed to evaluate the effects of aerobic exercise on adiponectin-1 levels and glycemic indices in adults with and without chronic diseases.
Methods: The PubMed, Web of Science, Scopus, Magiran, IranDoc, NoorMags, and SID databases were systematically searched up to September 23, 2025. To calculate the effect size, the standardized mean difference (SMD) with a 95% confidence interval was analyzed using a random-effects model in CMA2 software. Heterogeneity was assessed using the I² index, and publication bias was examined with funnel plots and Egger’s test.
Results: In total, 15 studies (including 16 aerobic exercise interventions) involving 409 adult participants with and without chronic diseases were included in the meta-analysis. The results indicated that aerobic exercise interventions led to a significant increase in adiponectin-1 (SMD=5.024, 95% CI: 3.571 to 6.477, p=0.001), a significant reduction in glucose (SMD= -2.409, 95% CI: -4.007 to -0.811, p=0.003), and insulin resistance (SMD= -1.519, 95% CI: -2.391 to -0.647, p = 0.001), compared to the control group in adults with and without chronic diseases. However, the effect of aerobic exercise on insulin levels (SMD= -1.187, 95% CI: -2.007 to -0.367, p = 0.005) was not statistically significant.
Conclusion: Aerobic exercise in adults with and without chronic disease likely leads to a significant increase in omentin-1 and is associated with improvements in glycemic indices, including glucose levels and insulin resistance. These findings indicate the positive effect of aerobic exercise on metabolic status and insulin sensitivity. However, the heterogeneity among studies and the limited sample sizes suggest that long-term studies with more diverse populations are necessary to fully understand the effects of exercise.
Methods: The PubMed, Web of Science, Scopus, Magiran, IranDoc, NoorMags, and SID databases were systematically searched up to September 23, 2025. To calculate the effect size, the standardized mean difference (SMD) with a 95% confidence interval was analyzed using a random-effects model in CMA2 software. Heterogeneity was assessed using the I² index, and publication bias was examined with funnel plots and Egger’s test.
Results: In total, 15 studies (including 16 aerobic exercise interventions) involving 409 adult participants with and without chronic diseases were included in the meta-analysis. The results indicated that aerobic exercise interventions led to a significant increase in adiponectin-1 (SMD=5.024, 95% CI: 3.571 to 6.477, p=0.001), a significant reduction in glucose (SMD= -2.409, 95% CI: -4.007 to -0.811, p=0.003), and insulin resistance (SMD= -1.519, 95% CI: -2.391 to -0.647, p = 0.001), compared to the control group in adults with and without chronic diseases. However, the effect of aerobic exercise on insulin levels (SMD= -1.187, 95% CI: -2.007 to -0.367, p = 0.005) was not statistically significant.
Conclusion: Aerobic exercise in adults with and without chronic disease likely leads to a significant increase in omentin-1 and is associated with improvements in glycemic indices, including glucose levels and insulin resistance. These findings indicate the positive effect of aerobic exercise on metabolic status and insulin sensitivity. However, the heterogeneity among studies and the limited sample sizes suggest that long-term studies with more diverse populations are necessary to fully understand the effects of exercise.
Type of Study: Review |
Subject:
Physiology
Received: 2025/12/24 | Accepted: 2025/07/1 | Published: 2025/03/20
Received: 2025/12/24 | Accepted: 2025/07/1 | Published: 2025/03/20
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |