Volume 31, Issue 3 (Summer 2025)
Intern Med Today 2025, 31(3): 0-0 |
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Mousavi Z S, Goli S, salmani F. Impact of Human Papillomavirus (HPV) Infection on Reproductive Outcomes in Infertile Couples Undergoing Assisted Reproductive Technology (ART): A Narrative Review . , Intern Med Today. 2025; 31 (3)
URL: http://imtj.gmu.ac.ir/article-1-4158-en.html
URL: http://imtj.gmu.ac.ir/article-1-4158-en.html
1- PhD in Reproductive and Sexual Health, Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
2- Department of Midwifery , Na.C., Islamic Azad University, Najafabad, Iran. Nursing and Midwifery Sciences Development Research Center, Na.C., Islamic Azad University, Najafabad, Iran.
3- Department of Nursing , Na.C., Islamic Azad University, Najafabad, Iran. Nursing and Midwifery Sciences Development Research Center, Na.C., Islamic Azad University, Najafabad, Iran. ,Fatemeh.salmani@iau.ac.ir
2- Department of Midwifery , Na.C., Islamic Azad University, Najafabad, Iran. Nursing and Midwifery Sciences Development Research Center, Na.C., Islamic Azad University, Najafabad, Iran.
3- Department of Nursing , Na.C., Islamic Azad University, Najafabad, Iran. Nursing and Midwifery Sciences Development Research Center, Na.C., Islamic Azad University, Najafabad, Iran. ,
Abstract: (26 Views)
Aims: Human papillomavirus (HPV) infection is highly prevalent during the reproductive years and may alter assisted reproductive technology outcomes through effects on sperm quality, fertilization, embryo development, and implantation. This study reviewed the association between HPV infection and reproductive outcomes among infertile couples undergoing assisted reproductive technology (ART).
Materials and Methods: In this narrative review, PubMed, Scopus, Web of Science, Embase, the Cochrane Library, PsycINFO, SID, Magiran, IranMedex, and Google Scholar were searched through July 2026. Observational studies evaluating HPV infection in the woman, the man, or both partners in relation to intrauterine insemination, in vitro fertilization, or intracytoplasmic sperm injection outcomes were included. A total of 14 studies were included in this review.
Findings: Four of the 14 studies reported significantly lower pregnancy or live-birth rates in HPV-positive participants, whereas 10 found no significant difference. Of the 12 studies evaluating miscarriage, three reported significantly higher miscarriage rates, whereas nine found no significant association. The only study evaluating preterm birth reported a higher rate among HPV-positive women. In that study, HPV infection was not independently associated with live birth after adjustment for confounders. Differences in sampling site, genotype, diagnostic method, treatment type, and sample size may explain the heterogeneous findings.
Conclusion: Current clinical evidence is insufficient to establish an independent and definitive adverse effect of HPV infection on assisted reproductive technology success. Well-designed prospective studies with adequate sample sizes, assessment of HPV genotypes and viral load, and rigorous control of confounding factors are required.
Materials and Methods: In this narrative review, PubMed, Scopus, Web of Science, Embase, the Cochrane Library, PsycINFO, SID, Magiran, IranMedex, and Google Scholar were searched through July 2026. Observational studies evaluating HPV infection in the woman, the man, or both partners in relation to intrauterine insemination, in vitro fertilization, or intracytoplasmic sperm injection outcomes were included. A total of 14 studies were included in this review.
Findings: Four of the 14 studies reported significantly lower pregnancy or live-birth rates in HPV-positive participants, whereas 10 found no significant difference. Of the 12 studies evaluating miscarriage, three reported significantly higher miscarriage rates, whereas nine found no significant association. The only study evaluating preterm birth reported a higher rate among HPV-positive women. In that study, HPV infection was not independently associated with live birth after adjustment for confounders. Differences in sampling site, genotype, diagnostic method, treatment type, and sample size may explain the heterogeneous findings.
Conclusion: Current clinical evidence is insufficient to establish an independent and definitive adverse effect of HPV infection on assisted reproductive technology success. Well-designed prospective studies with adequate sample sizes, assessment of HPV genotypes and viral load, and rigorous control of confounding factors are required.
Keywords: Assisted Reproductive Technology, Human Papillomavirus, Infertility, Miscarriage, Pregnancy
Type of Study: Review |
Subject:
Obstetrics and Gynecology
Received: 2024/11/27 | Accepted: 2025/03/28 | Published: 2025/05/30
Received: 2024/11/27 | Accepted: 2025/03/28 | Published: 2025/05/30
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