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Background and Aim: Acute renal failure is a common complication of cardiac surgery and oxidants and diabetes play an important role in renal injury in this condition. In this study, we aimed to assess whether vitamin E as a supplemental antioxidant and allopurinol as an oxygen radical antagonist could prevent renal dysfunction after coronary artery bypass graft (CABG) surgery. Materials and Methods: eighty diabetic patients with GFR less than 60 ml/min undergoing CABG surgery were randomized into two groups: treated with vitamin E and allopurinol (group A: n=40) and without treated (group B: n=40). Diabetic patients were detected. Group A, drugs 3 to 5 days before surgery. Serum creatinine, potassium, creatinine clearance and urine output were measured preoperatively and daily until day 5 after surgery. Results: The patients consisted of 41 males and 39 females with a mean age of 63±9 years. The mean serum creatinine and creatinine clearance were 1.3±0.5 mg/dl (0.8±3 mg/dl) and 48±10 ml/min (22-68 ml/min), respectively. There were no differences in baseline variables such as age, body mass index, sex, hypertension, diabetes, duration of operation and aorta cross clump, serum creatinine and potassium, and creatinine clearance between the groups. When comparing two groups, there were no significant differences in mean of variables before and after operation such as serum creatinine (1.2±0.4 vs. 1.2±0.3 mg/dl, p=0.4), serum potassium (4.3±0.3 vs. 4.4 ±0.3 meq/l, p=0.7). Length of intensive care unite stay in control group was more than treated group (3.8±1.2 vs. 2.8±0.5 day, p=0.00). Conclusion: Prophylactic treatment with vitamin E and allopurinol have no Reno protective effect in these patients but these two drugs can decrease hospitalization in ICU with intervention by two drugs.

Keywords: CABG; Acute Renal Failure; Diabetes

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