Volume 18, Issue 1 (2012; Vol. 18, No. 2 2012)                   Intern Med Today 2012, 18(1): 12-16 | Back to browse issues page

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1- University of medical sciences , rkomeili@gmail.com
2- Faculty of medicine
3- Physiology Lab
Abstract:   (13090 Views)
Abstract Background and Aim: Non-steroidal anti-inflammatory drugs have been used widely in recent times and generation of peptic ulcer is a side-effect of these drugs. In this study, we evaluated the effect of extract of Carum Copticum seed on treatment of peptic ulcer induced by ibuprofen in rats. Materials and Methods: This study was performed on 30 adult female rats. At first, the animals were randomly divided into five groups. Then, in order to induce gastric ulcer, Ibuprofen was used orally. After suffering, the animals were treated with Omeprazole or plant seed aqueous extract doses of 125, 250 and 500 mg per kg, twice a day for two weeks. Finally, the animals were studied in terms of the number and the extent of gastric ulcer. The amount of liver enzymes, Aspartate Transferase (AST) and Alkaline Transferase (ALT), in the serum of animals were also measured. Results: The plant seed extract caused a dose-dependent ulcer healing effect in rats, that is, the therapeutic effect in doses of 125 and 250 mg/kg compared with Omeprazole was significantly meaningful (p<0.05). The mean number and area of gastric ulcers in the groups receiving the extract were significantly lower than those of the group receiving Omeprazole. The amount of liver enzymes in the extract group that received a dose of 500 mg/kg significantly increased (p<0.01). Conclusion: The extract of Carum Copticum seed was very effective in the treatment of peptic ulcer and therapeutic effect of this extract is comparable with that of Omeprazole. Moreover, further work is needed to elucidate the extent and mechanism of these changes.
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Type of Study: Original | Subject: Basic Medical Science
Received: 2010/06/23 | Accepted: 2012/05/2 | Published: 2012/04/15

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