Dr Seyyed Mohammad Ali Raisolsadat, Dr Mohammad Ali Yaghoubi, Dr Pejman Hafez, Dr Ali Mirsadeghi, Dr and Mojgan Zarif, Volume 16, Issue 2 (10-2010)
Abstract
Abstract
Focal nodular hyperplasia (FNH), after hemangioma, is the second most common benign tumor of the liver. Rupture and hemorrhage in FNH is rare. To the best of our knowledge, only eight cases of rupture and hemorrhage in FNH have been reported in English literature. A 40-year-old woman presented acute onset of right upper quadrant pain. Ultrasonography of the abdomen demonstrated a large sub-capsular hematoma along the right side of the liver with non-homogenous mass with a diameter of10 cm. Abdominal CT scan with IV contrast revealed a huge sub-capsular hematoma in the posterior segment in the right lobe of the liver. The patient underwent surgery with presumptive diagnosis of hemorrhagic adenoma. During the operation, we noticed a nodular center in the resected liver mass. Pathologic examination revealed Focal Nodular Hyperplasia (classical type) in Right Liver lobe with extensive hemorrhage and necrosis. This is the first report of ruptures and hemorrhage in FNH in Iran which must be distinguished from liver adenoma.
Background: Non-alcoholic Fatty Liver Disease (NAFLD) is one of the most common chronic liver diseases worldwide and oxidative stress (OS) is one of the most important factors of pathophysiology in the development of this disease. The use of antioxidant agents for preventing and treating NAFLD has been suggested in several studies. Due to the antioxidant function of curcumin, the effects of curcumin on serum level of malondialdehyde (MDA) as an oxidative stress marker and enzymes activity level of catalase (CAT) and superoxide dismutase (SOD) were investigated in this study. Methods: In this study, 70 patients with NAFLD were selected and distributed through randomized blocks in two groups of receiving curcumin 500mg plus piperine 5mg and placebo. CAT and SOD markers were measured by photometric method and MDA marker by calorimetric method before and after the intervention. Findings: Comparison of the changes in the serum level of MDA factor and the activity of CAT and SOD enzymes in the serum of the studied patients after the intervention showed that the serum activity of catalase enzyme increased significantly due to the consumption of the combination of curcumin 500 mg and piperine 5 mg (p = 0.008) while SOD and MDA factors did not show any significant difference in the two studied groups. Conclusion: The results indicate that daily use of curcumin in patients with NAFLD can increase the serum activity of catalase. According to the results of this study, the use of curcumin as a natural supplement, might be effective in blunting the negative effects of oxidative stress in patients with NAFLD.
