Showing 4 results for قوجق
Dr. Z. Hoozyari, Dr. S. Kannai, Dr. D. Qujeq, Dr. F. Ouliaei, Dr. K. Aghcheli,
Volume 13, Issue 1 (vol-1 2007)
Abstract
Background and Aim: 5- aminolevulinic acid dehydratase is the second enzyme in the heme biosynthetic pathway. This enzyme catalyzes the delta-aminolevulinic acid to prophobilinogen. Because there have been few studies in chronic renal failure, we thought it useful in patients with chronic renal failure. Thus, the goal of this study is to measure 5- aminolevalinate dehydratase activity in patients with chronic renal failure.
Materials and Methods: Blood was obtained from patients with chronic renal failure for 5- aminolevulinate dehydratase activity determination in erythrocytes. Measurement was based upon the conversion of uminolevulinic acid to porphobilinogen, which is then measured spectrophotometrically.
Results: Our results showed that 5-aminolevulinate dehydratase activity was (634.7±21.2 micromol/L/min) in patient group and in control group was (825.4±23.6 micromole/L/min).
Conclusions: Our results showed that 5-aminolevulinate dehydratase activity was decreased in patients with chronic renal failure when compared to control group. These results showed that this enzyme may be inhibited in patients group.
Dr. A. Sharifi Kh, Dr. D. Qujeq, Dr. B. Yousef Ghahhary,
Volume 15, Issue 1 (vol.15-2 2009)
Abstract
Background and Aim: There is not a suitable marker in dilution method in analysis of biomarker in joint fluid. In past, dye dilution method was used for joint fluid, but there were some errors. The aim of this work is the use of rate change lactate level in serum and synovial fluid of patients with arthritis by application of dilution method and direct aspiration as a biomarker.
Materials and Methods: In this cross-sectional study synovial fluid were obtained from 30 arthritis patients by direct aspiration. Also, serum sample were obtained from these patients. Serum and synovial fluid Lactate level was measured by standard biochemical methods. For analysis results Students t-test was used and P was less than 0.05.
Results: Lactate concentration increases in synovial fluid (14.1 ±2.3 mg/dl) in compare with serum (12.9 ± 2.1 mg/dl), but the differences were not significant.(p>0.05).
Conclusion: The difference between lactate concentration in synovial fluid and serum is not significant. The rate change of lactate concentrations in synovial fluid and serum was stable.
Dr. D. Qujeq, Dr. Aj. Ahmadi Ahangar, Me. Shahabadin, M. Zande Emami,
Volume 15, Issue 2 (Vol.15-3 2009)
Abstract
Background and Aim: Previous studies were carried out on blood subjects with migraine. Blood calcium and magnesium don’t reflect the body content of it. This research was designed to measure intra cellular magnesium and calcium concentration. The aim of this study was to measure red blood cell magnesium and calcium in patients with migraine.
Materials and Methods: In this research Red blood cell magnesium and calcium concentration were measured in 21 patients with migraine and 24 normal subjects without migraine. Magnesium and calcium levels were determined by atomic absorption.
Results: In this study differences between the magnesium and calcium levels in the two study groups were found. In comparison with normal subjects, migraine patients had higher red blood cell magnesium levels (8.409 ± 0.516, 7.866 ±0.687 mg/ml, p>0.05). Also, In comparison with normal subjects, migraine patients had higher red blood cell calcium levels (14.255 ±0.453, 3.799 ±0.176 mg/ml, p<0.05). The data were expressed as the mean ± the standard deviation, and they were statistically analyzed with Student t-test.
Conclusion: Change calcium, magnesium level in migraine agreement with previous studies of a possible role for magnesium and calcium in migraine patients. Therefore, according to our data changing magnesium and calcium levels is related to migraine pathophysiology. In future with control calcium and magnesium level in migraine patients, we can use for improving the status.
Ghojagh D., Deylam Katoli H., Habibi Nodeh M.,
Volume 19, Issue 3 (Autumn 2013)
Abstract
Aims: Diabetes is a world wide health threat and treatment of this disease is very important in medical sciences. The aim of this investigation was to determine the carbonyl and malondialdehyde levels and glutathione peroxides activity in the erythrocytes of diabetic rats.
Methods: In this experimental study, 24 rats with 180-220g body weight were divided into two control and diabetic groups. Diabetic status was induced by intraperitoneal injection of alloxan. Malondialdehyde and carbonyl levels and glutathion peroxidase activity were measured by using special kits. Mean and diviation of data were calculated by SPSS 18 software and the difference of two groups was compared by student T test.
Results: The mean of malondialdehyde level in erythrocyte of diabetic group (2.27±0.22mmol/mg of protein) was increased compared to control group (1.16±0.15mmol/mg of protein p<0.05). Mean of carbonyl content in erythrocytes of diabetic group (2.98±0.35 mmol/mg of protein) was increased compared to control group (0.75±0.17mmol/mg of protein p<0.05). Mean of glutathion peroxidase activity level in erythrolytes of diabetic group (5.73±0.46 m molNADPH/min/mg of protein) was increased compared to control group (2.98±0.33 m molNADPH/min/mg of protein p<0.05).
Conclusion: Mean levels of carbonyl and malondialdehyde and glutathion peroxidase activity increases in diabetic rats compare to non-diabetic rats.
