Shahraki M.r., Mirshekari H., Khamar Moghadam S.,
Volume 19, Issue 2 (6-2013)
Abstract
Aims: Diabetes mellitus is a metabolic disorder which caused by hyperglycemia. Since the serum magnesium level plays an important role in obvious diabetes side effects, the aim of this survey was to evaluate the effect of oral magnesium sulfate administration on blood glucose and serum lipids in streptozotocin-induced diabetic male rats.
Methods: This experimental study was performed on 32 Wistar-Albino male rats, which were weighed between 200-250gr. One half of animals were given intra peritoneal injection of 50mg/kg streptozotocin solution which was prepared in sodium citrate buffer. Rats were divided into two healthy A and B groups and two diabetic C and D groups. A and C groups’ samples were feed by rodent's diet and tap water but B and D groups’ samples received normal diet and water containing 10mg/ml magnesium sulfate during the experiment. At the end of the experiment, serum glucose and lipoprotein profile of rats were measured. Obtained data were analyzed by SPSS 17 using ANOVA and Tukey tests.
Results: Blood glucose, serum Triglyceride and LDL level in group D were significantly decreased compared to those of group C, but there was no significant difference in the HDL and total cholesterol level between groups C and D.
Conclusion: Oral magnesium sulfate consumption cause in blood glucose decreasing and serum lipoprotein profile improvement in streptozotocin-induced diabetic male rats.
Maryam Farazande, Sadegh Shabab, Maryam Mahmoudabady, Zahra Gholamnezhad,
Volume 28, Issue 1 (12-2021)
Abstract
Aims: Nowadays, herbal medicine is commonly used due to the side effects and high costs of chemical medicines. Cinnamon appears to be effective in the prevention and treatment of a variety of diseases, which is used in both food industry and traditional medicine. This study aims to review the effects of cinnamon on the occurrence of cardiovascular diseases and their related risk factors.
Methods & Materials: In this review study, the search was conducted using the keywords in English including Cinnamon, Cinnamomum, Cinnamaldehyde and Heart, Cardiac, and Cardiomyopathy based on MeSH terms and the keywords in Persian for the related articles in Web of Sciences, PubMed, ScienceDirect, Scopus, Google Scholar, and Scientific Information Database (SID) databases published until March 2021. Out of 205 studies, 51 experimental and clinical human and animal studies were reviewed.
Findings: The results of studies reported the effects of cinnamon on the risk factors of cardiovascular diseases such as hyperlipidemia, hypertension and oxidative stress.
Conclusion: The majority of human and animal studies have shown that cinnamon prevent and treat cardiovascular diseases by lowering oxidative stress and improving blood pressure and blood lipid parameters.
