TY - JOUR JF - QHMS JO - Intern Med Today VL - 20 IS - 4 PY - 2015 Y1 - 2015/1/01 TI - Effect of Intense Exercise Training on Hydrogen Peroxide, Tumor Necrosis Factor-Alpha and the Selected Neurotrophins in Rat’s Brain TT - اثر تمرین ورزشی شدید بر پراکسیدهیدروژن، عامل نکروز تومور آلفا و نروتروفین‌های منتخب در مغز موش صحرایی N2 - Aims: Alpha tumor necrosis factor and Hydrogen peroxide increase in neurotrophins expression in several brain structures. The purpose of this study was to investigate the interactive effect of Hydrogen peroxide and neurotrophic tumor necrosis factor with brain-derived neurotrophic factor by glial cell-derived neurotrophic factor after severe exercise. Materials & Methods: This experimental study was done on 16 adult Wistar albino rats 280g and 3months old. Animals were divided into two intense exercise and sedentary control groups. Animals ran for 6 weeks, 6 days a week, at the speed of 27m per minute and on treadmill for 60 minutes daily. Using kit, the content of BDNF, GDNF, and TNF-α were measured using sandwich ELISA and hydrogen peroxide levels was analyzed by colorimetric assay. Data analyzed by SPSS 16 and Independent-T test. Findings: Hydrogen peroxide levels in the brain, in intense exercise group increased significantly compared with control group (p= 0.006). TNF-α, GDNF and BDNF Levels in the brain in intense exercise group significantly increased compared with control group (p=0.001). Conclusion: Intense running on treadmill increase BDNF and GDNF content in brain of albino Wistar rats through increasing the H2O2 and TNF-α levels. SP - 231 EP - 236 AU - Taheri Chadorneshin H., AU - Afzalpour M.E., AU - Abtahi H., AU - Foadoddini M., AD - Exercise Physiology Department, Education and Sport Sciences Faculty, Birjand University, Birjand, Iran KW - Exercise [http://www.ncbi.nlm.nih.gov/mesh/68015444] KW - Oxidative Stress [http://www.ncbi.nlm.nih.gov/mesh/68018384] KW - Hydrogen Peroxide [http://www.ncbi.nlm.nih.gov/mesh/68006861] KW - Glial Cell Line-Derived Neurotrophic Factor[http://www.ncbi.nlm.nih.gov/mesh/68 UR - http://imtj.gmu.ac.ir/article-1-2078-en.html DO - 10.18869/acadpub.hms.20.4.231 ER -