RT - Journal Article T1 - The Effect of an Incremental Training Rehabilitation Period on the Serum Levels of Pentraxin-3 and Osteoprotegerin in Rats With Myocardial Infarction JF - QHMS YR - 2022 JO - QHMS VO - 28 IS - 3 UR - http://imtj.gmu.ac.ir/article-1-3871-en.html SP - 366 EP - 381 K1 - Myocardial infarction K1 - Incremental training rehabilitation K1 - Pentraxin-3 (PTX3) K1 - Osteoprotegerin AB - Aims Activation of inflammatory processes is necessary immediately after myocardial infarction (MI), but if it continues excessively, it can facilitate the occurrence of MI. Considering the positive effects of exercise on inflammatory pathways and their reduction, it seems to play a crucial role in improving the condition of MI patients. Accordingly, the present study investigated the effect of an incremental training rehabilitation period on serum levels of pentraxin-3 and osteoprotegerin in infarcted rats. Methods & Materials In this experimental study controlled with a control group, 36 Wistar rats (8 weeks old, weighing 210±26 g) were randomly divided into 3 groups, healthy, MI, and infarction-incremental training rehabilitation. MI was then induced in two infarction groups using two subcutaneous injections of isoproterenol (150 mg/kg) at 24-hour intervals. The intervention groups underwent incremental endurance training for one session (treadmill with a speed of 10 m/min and a start time of 20 minutes and reached a speed of 18 m/min and a time of 50 minutes). Serum levels of pentraxin-3 (PTX3) and osteoprotegerin (OPG) were then assessed by ELISA immediately after the intervention. One-way analysis of variance and Tukey post hoc tests were used to analyze the data at the significance level of P LA eng UL http://imtj.gmu.ac.ir/article-1-3871-en.html M3 10.32598/hms.28.3.3706.1 ER -