fa ﺗﺄﺛﯿﺮ ﺗﻤﺮیﻦ دوره‌ای و ﻣﺼﺮف ﻋﺼﺎره داﻧﻪ ﺷﻨﺒﻠﯿﻠﻪ ﺑﺮ ﺑﯿﺎن ژن FGF-21 و VEGF در ﺑﯿﻤﺎران ﻣﺒﺘﻼ ﺑﻪ ﺑﯿﻤﺎری ﻋﺮوق ﮐﺮوﻧﺮ مطالعه بيماری‌ها Diseases پژوهشی Original <strong>اهداف:&nbsp;</strong>رژیﻢ ﻏﺬایﯽ ﭘﺮﭼﺮب، اﺳﺘﻌﻤﺎل دﺧﺎﻧﯿﺎت و ﺑﯽ‌ﺗﺤﺮﮐﯽ از دﻻیﻞ ﻋﻤﺪه ﺑﯿﻤﺎری ﻋﺮوق ﮐﺮوﻧﺮ (CAD) اﺳﺖ. ایﻦ ﻣﻄﺎﻟﻌﻪ ﺑﺎ هدف ﺑﺮرﺳﯽ ﺗﺄﺛﯿﺮ ﺗﻤﺮیﻦ دوره‌ای همراه ﺑﺎ ﻣﺼﺮف ﻋﺼﺎره داﻧﻪ ﺷﻨﺒﻠﯿﻠﻪ ﺑﺮ ﺑﯿﺎن ژن FGF-21 و VEGF در ﺑﯿﻤﺎران ﻣﺒﺘﻼ ﺑﻪ CAD اﻧﺠﺎم ﺷﺪ.<br> <strong>مواد و روش ها:</strong> ایﻦ ﻣﻄﺎﻟﻌﻪ ﻧﯿﻤﻪ‌ﺗﺠﺮﺑﯽ روی 32 ﺑﯿﻤﺎر ﻣﺮد ﻣﺒﺘﻼ ﺑﻪ CAD اﻧﺠﺎم ﺷﺪ ﮐﻪ ﺳﻦ آن‌ها ﺑﯿﻦ 55 ﺗﺎ 65 ﺳﺎل ﺑﻮد. این افراد ﺑﻪ ﻃﻮر ﺗﺼﺎدﻓﯽ ﺑﻪ ﭼﻬﺎر ﮔﺮوه ﮐﻨﺘﺮل، ﻓﻘﻂ تمرین، ﻓﻘﻂ ﺷﻨﺒﻠﯿﻠﻪ و ﮔﺮوه‌ تمرین+‌ﺷﻨﺒﻠﯿﻠﻪ ﺗﻘﺴﯿﻢ ﺷﺪند. ﺑﺮﻧﺎﻣﻪ تمرینی ﺷﺎﻣﻞ هشت هفته ﺗﻤﺮیﻦ دویﺪن ﺑﺎ ﻓﺎﺻﻠﻪ زﻣﺎﻧﯽ، ﺳﻪ ﺟﻠﺴﻪ در هفته ﺑﺎ ﺷﺪت 55 تا 65 درصد ذﺧﯿﺮه ﺿﺮﺑﺎن ﻗﻠﺐ و ﺑﺎ اﻓﺰایﺶ ﺗﺪریﺠﯽ ﺷﺪت ﺑﻮد. اﻓﺮاد روزاﻧﻪ ده ﻣﯿﻠﯽ‌ﮔﺮم ﻋﺼﺎره ﺷﻨﺒﻠﯿﻠﻪ ﻣﺼﺮف ﮐﺮدﻧﺪ. ﺑﺮای اﻧﺪازه‌ﮔﯿﺮی ﺑﯿﺎن ژن‌های FGF-21 و VEGF از PCR در زﻣﺎن واﻗﻌﯽ اﺳﺘﻔﺎده ﺷﺪ.<br> <strong>یافته ها:</strong> ﻣﯿﺎﻧﮕﯿﻦ ﻧﺴﺒﺖ ﺑﯿﺎن FGF21 در گروه‌های ﻓﻘﻂ تمرین، ﻓﻘﻂ ﺷﻨﺒﻠﯿﻠﻪ و تمرین+‌ﺷﻨﺒﻠﯿﻠﻪ ﺑﻪ ﻃﻮر ﻗﺎﺑﻞ ﺗﻮﺟﻬﯽ ﺑﺎﻻﺗﺮ از ﮔﺮوه ﮐﻨﺘﺮل ﺑﻮد (P<0/0001). ﮔﺮوه تمرین+‌ﺷﻨﺒﻠﯿﻠﻪ از ﻧﻈﺮ آﻣﺎری اﻓﺰایﺶ معنی‌دار ﺑﯿﺸﺘﺮی نسبت به ﮔﺮوه‌های ﻓﻘﻂ تمرین و ﻓﻘﻂ ﺷﻨﺒﻠﯿﻠﻪ داشت (P‌<0/0001). ﻋﻼوه ﺑﺮ ایﻦ، ﻣﯿﺎﻧﮕﯿﻦ ﺿﺮیﺐ ﺗﻐﯿﯿﺮات (CV) ﺑﯿﺎن ژن VEGF در ﮔﺮوه ﻓﻘﻂ تمرین (P‌<0/0001)، ﻓﻘﻂ ﺷﻨﺒﻠﯿﻠﻪ (P‌=‌0/0004) و تمرین+‌ﺷﻨﺒﻠﯿﻠﻪ (P‌<0/0001) ﺑﻪ ﻃﻮر ﻗﺎﺑﻞ ﺗﻮﺟﻬﯽ ﺑﯿﺸﺘﺮ از گروه ﮐﻨﺘﺮل ﺑﻮد. همچنین ﮔﺮوه تمرین+‌ﺷﻨﺒﻠﯿﻠﻪ اﻓﺰایﺶ معنی‌دار ﺑﯿﺸﺘﺮی نسبت به ﮔﺮوه ﻓﻘﻂ تمرین (P‌=‌0/0181) و ﻓﻘﻂ ﺷﻨﺒﻠﯿﻠﻪ (P‌<0/0495) نشان داد.<br> <strong>نتیجه گیری:</strong> ﺗﺮﮐﯿﺒﯽ از تمرین دوره‌ای و ﻣﺼﺮف ﻋﺼﺎره داﻧﻪ ﺷﻨﺒﻠﯿﻠﻪ، ﻣﻮﻓﻖ ﺑﻪ اﻓﺰایﺶ CV ﺑﯿﺎن ژن FGF21 و VEGF می‌شود؛ ﺑﻨﺎﺑﺮایﻦ ﻣﯽ‌ﺗﻮاﻧﺪ اﺛﺮات ﻣﻔﯿﺪی در ﻣﺴﯿﺮ آﻧﮋیﻮژﻧﺰ در ﺑﯿﻤﺎران ﺑﺎ اﻧﺴﺪاد ﺷﺮیﺎن ﮐﺮوﻧﺮ داﺷﺘﻪ ﺑﺎﺷﺪ. <strong>Aims:</strong> A high-fat diet, smoking, and a sedentary lifestyle are the major causes of Coronary Artery Disease (CAD). This study aimed to explore the effect of interval training and the consumption of fenugreek seed extract on FGF-21 and VEGF gene expression among patients with CAD.<br> <strong>Methods & Materials:</strong> The present quasi-experimental study was conducted on a sample of 32 male patients with CAD, aged between 55 and 65 years. They were randomly divided into four groups: control, training only, fenugreek only, and training + fenugreek. The training program consisted of eight weeks of interval running, three sessions per week with an intensity of 55% and 65% of heart rate reserve, with a gradually increasing intensity. Subjects consumed 10 mg/kg of fenugreek extract daily. Real-time PCR was used to measure the expression of FGF-21 and VEGF genes.<br> <strong>Findings:&nbsp;</strong>The results showed that the mean expression ratios of FGF-21 in training only, fenugreek only, and training + fenugreek groups were significantly higher than the control group (P<0.0001). The fenugreek + training group had a greater significant increase (P<0.0001) more than the training + fenugreek group. Moreover, the mean Coefficient of Variation (CV) of VEGF gene expression was significantly increased more than that in the training group (P<0.0001), fenugreek group (P=0.0004), and the training + fenugreek group (P<0.0001), compared to the control group. The fenugreek + training group had a greater and more significant increase than the training only (P=0.0181) and the fenugreek only groups (P<0.0495).<br> <strong>Conclusion:&nbsp;</strong>The results showed that a combination of interval training and consumption of fenugreek seed extract increased the CV of FGF-21 and VEGF gene expression and thus, have beneficial effects on the angiogenesis pathway in patients with CADs.<br> <span dir="RTL"></span> تمرین دوره‌ای؛ ﺷﻨﺒﻠﯿﻠﻪ؛ ﻓﺎﮐﺘﻮر رﺷﺪ ﻓﯿﺒﺮوﺑﻼﺳﺖ (FGF-21‌)؛ ﻓﺎﮐﺘﻮر رﺷﺪ اﻧﺪوﺗﻠﯿﺎل عروﻗﯽ (VEGF)؛ ﺑﯿﻤﺎری ﻋﺮوق ﮐﺮوﻧﺮ Interval training, Fenugreek, Fibroblast Growth Factor (FGF21), Vascular Endothelial Growth Factor (VEGF), Coronary artery disease 130 147 http://imtj.gmu.ac.ir/browse.php?a_code=A-10-3456-1&slc_lang=fa&sid=1 Ebad Roohbakhsh عباد روحبخش roohbakhsh1987@yahoo.com 8000319475328460033807 8000319475328460033807 No Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran. ﮔﺮوه ﻓﯿﺰیﻮﻟﻮژی ورزﺷﯽ، واﺣﺪ آیﺖ‌اﷲ آﻣﻠﯽ، داﻧﺸﮕﺎه آزاد اﺳﻼﻣﯽ، آﻣﻞ، ایﺮان. Alireza Barari علیرضا براری alireza54.barari@gmail.com 8000319475328460033808 8000319475328460033808 Yes Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran. ﮔﺮوه ﻓﯿﺰیﻮﻟﻮژی ورزﺷﯽ، واﺣﺪ آیﺖ‌اﷲ آﻣﻠﯽ، داﻧﺸﮕﺎه آزاد اﺳﻼﻣﯽ، آﻣﻞ، ایﺮان. Hajar Abbaszadeh هاجر عباس زاده h.abaszade61@gmail.com 8000319475328460033809 8000319475328460033809 No Department of Sport Physiology, Sari Branch, Islamic Azad University, Sari, Iran. ﮔﺮوه ﻓﯿﺰیﻮﻟﻮژی ورزﺷﯽ، واﺣﺪ ﺳﺎری، داﻧﺸﮕﺎه آزاد اﺳﻼﻣﯽ، ﺳﺎری، ایﺮان.