Internal Medicine Today

fa بررسی رابطه تمرینات ورزشی با MOTS-c در دیابت نوع 2: یک مطالعه مروری Investigating the relationship between exercise training and MOTS-c in type 2 diabetes: a review study مطالعه بيماری‌ها Diseases مروری Review <div style="text-align: justify;"> اهداف: دیابت نوع ۲ بیماری مزمنی است، که امید به زندگی در مبتلایان به آن بخاطر برخی مشکلات  پایین می آید. اختلال عملکرد میتوکندری یک ویژگی برجسته در دیابت نوع 2 است. MOTS-C  یک پپتید مشتق از میتوکندری با فعالیت تقلیدی ورزشی است که اثرات مفیدی بر متابولیسم و ظرفیت ورزش دارد . هدف از این مقاله، مروری بر عملکرد پپتید  MOTS-c   و مکانیسم عمل تمرینات ورزشی بر بهبود بیماری دیابت نوع 2 می باشد. مواد و روش ها: این مطالعه مروری، با جستجو در مقاله های موجود در پایگاه های اطلاعاتی، ,Scapus ,Google scholar ,Pubmed و فارسی شامل ،    Magiraو با کلید واژه های  MOTS-c، دیابت نوع 2، تمرینات ورزشی مربوط به سال های 1991 تا 2022 انجام گردید. جستجو به مقالات با زبان انگلیسی و فارسی که متن کامل آن ها موجود بود، محدود گردید. به طور کلی از بین 52 مقاله بدست آمده، 41 مقاله که متن کامل آن ها موجود بود، مورد بررسی قرار گرفت. یافته ها :تمرینات ورزشی سطح MOTS-c را افزایش داده و MOTS-C، AMPK   را در عضلات اسکلتی فعال می کند و متابولیسم انرژی کل بدن را بهبود می بخشد. نتیجه گیری: تمرین ورزشی حساسیت به انسولین را بهبود می بخشد و  خطر ابتلا به بیماری های همراه را کاهش می دهد.  </div> <div aria-hidden="true" class="UdTY9 WdefRb" data-location="2" jsaction="agoMJf:gXkcrf;h5CHLc:RHer4,P6Fjxb;rpiAHc:GitQp,fNH7he" jscontroller="ZbunN" jsname="c3wAjc"><div jsname="jTaUub" class="kO6q6e"></div></div> <div class="VO9ucd" jsaction="JIbuQc:WDL0xb(vLv7Lb),DSQAtf(kImuFf),ZRWqcb(kImuFf),FeoNK(rhPddf),X9gwPe(rhPddf)"> <div class="aJIq1d nzsIKe" data-crosslingual-hint="" data-enable-toggle-playback-speed="true" data-language-code="en" data-language-name="انگلیسی" data-location="2" data-text="Abstract Objective: Type 2 diabetes is a chronic disease, which lowers the life expectancy of its sufferers due to the occurrence of some problems. This issue is partly due to some of the complications that this disease brings. The increase in the number of people with type 2 diabetes In 2015, 415 million people had diabetes, more than 90% of them had type 2 diabetes, which is expected to increase to 642 million people by 2040. Studies show that mitochondrial dysfunction is a prominent feature of type 2 diabetes. MOTS-C is a mitochondrial-derived peptide with exercise-mimicking activity that has beneficial effects on metabolism and exercise capacity. MOTS-c stimulates glucose utilization, lipid oxidation, reduces inflammation, and protects against experimental models of metabolic disease. Researchers are looking for alternative methods for prevention or treatment with less complications in diabetic patients, and considering the importance of exercise in preventing complications of type 2 diabetes and the effect it has on the mechanism of mitochondrial peptides; Methods that reduce mitochondrial function disorders will provide a new horizon in the treatment of diabetes and its complications. Therefore, the purpose of this article is to review the performance of MOTS-c peptide and the mechanism of action of exercise training on the improvement of type 2 diabetes. Methodology: This review study, by searching in the articles available in the databases, Scapus, Google scholar, Pubmed and Farsi including, SID, Magira and with keywords MOTS-c, type 2 diabetes, sports exercises related to the year from 1991 to 2021. The search was limited to articles in English and Farsi whose full text was available. In general, among the 52 articles obtained, 41 articles whose full text was available were examined. Findings and results: Studies have shown that exercise increases the level of MOTS-c and MOTS-C activates AMPK in skeletal muscles and improves the energy metabolism of the whole body. Also, it improves insulin sensitivity and thus reduces the risk of associated diseases. Suggestions: According to the findings of the articles, it seems that exercise exercises have beneficial effects on the MOTS_c peptide. In addition, insight into such mechanisms can be a basis for the prevention and treatment of metabolic and chronic diseases associated with physical inactivity. However, it is necessary to conduct more research on the effectiveness of various types of exercise with different intensities and It should also be done by considering different variables such as age, sex, being an athlete and non-athlete." jsaction="click:Gbxe1; mouseover:hhMOkf;JIbuQc:PreYxb;OBoCn:mVk5Z,lCU3Od;Ty8gnd:HPNHWd;NWKMf:kyVNJ;vcrU3d:Zlhgrb,UK2BE,AF7SHc,nkwrxd;HOIUFe:HPNHWd,kyVNJ,SuUFRb;Q8Drrd:HPNHWd,kyVNJ,vnX0N;aTptWe:Ln2vo;vvtHud:oKcBzb,xFzAKb;l1LAxc:nEgk5e" jscontroller="JNcm2e" jsmodel="WCciof" jsname="Xk9Utf"> <div class="m0Qfkd"></div> </div> </div> Aims: Type 2 diabetes is a chronic disease, which lowers the life expectancy of its sufferers due to some problems. Mitochondrial dysfunction is a prominent feature in type 2 diabetes. MOTS-C is a mitochondrial-derived peptide with sports-mimicking activity that has beneficial effects on metabolism and exercise capacity. The purpose of this article is to review the performance of MOTS-c peptide and the mechanism of action of exercise training on the improvement of type 2 diabetes. Materials and methods: This review study, by searching in the articles available in the databases, Scapus, Google scholar, Pubmed and Farsi including,   Magira and with the keywords MOTS-c, type 2 diabetes, sports training related to the years 1991 to 2022 was done. The search was limited to articles in English and Farsi whose full text was available. In general, among the 52 articles obtained, 41 articles whose full text was available were examined. Findings: and conclusions: Exercise training increases the MOTS-c level and MOTS-C activates AMPK in skeletal muscles and improves the energy metabolism. Conclusion:Exercise training improves insulin sensitivity, reducing the risk of concomitant diseases.   دیابت نوع2, تمرینات ورزشی, میتوکندری ,MOTS-c Exercise training,mitochondria , MOTS-c,type 2 diabetes 44 54 http://imtj.gmu.ac.ir/browse.php?a_code=A-10-3892-1&slc_lang=fa&sid=1 Sahar Parseh سحر پارسه saharnazparse@gmail.com 8000319475328460037258 8000319475328460037258 Yes Department of Sports Physiology, Faculty of Sports Sciences and Physical Education, Shahid Chamran Ahvaz, Ahvaz, Iran. گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی و تربیت‌بدنی، شهید چمران اهواز، اهواز، ایران. Saeid Shakeriyan سعید شاکریان S.SHKERYAN@SCU.AC.IR 8000319475328460037259 8000319475328460037259 No Department of Sports Physiology, Faculty of Sports Sciences and Physical Education, Islamic Azad University, Yasuj, Iran. گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی و تربیت‌بدنی، علوم و تحقیقات، یاسوج، ایران. Omid Zafarmand امید ظفرمند OMIDZAFARMAND2202@GMAIL.COM 8000319475328460037260 0009-0000-5959-0058 No Department of Sports Physiology, Faculty of Sports Sciences and Physical Education, Islamic Azad University, Yasuj, Iran. گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی و تربیت‌بدنی، علوم و تحقیقات، یاسوج، ایران.