en بررسی یافته‌های تصویربرداری تشدید مغناطیسی در بیماران ‌مبتلا به ‌میگرن در مقایسه با افراد بدون میگرن مراجعه کننده به ‌بیمارستان علامه بهلول ‌گناباد: یک مطالعه مورد شاهد پزشكي داخلی Internal Medicine پژوهشی Original <span style="font-size:11pt"><span style="line-height:115%"><span style="tab-stops:446.5pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">مقدمه و هدف</span></span></span></b><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">: </span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">اختلالات سردرد و میگرن یکی از مهم</span></span></span><span dir="LTR" lang="AR-SA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">&lrm;</span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">ترین معضلات عصر حاضر بوده که می</span></span></span><span dir="LTR" lang="AR-SA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">&lrm;</span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">تواند منجر به ناتوانی</span></span></span><span dir="LTR" lang="AR-SA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">&lrm;</span></span></span><span lang="AR-SA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">های &rlm;شدید &rlm;در کارهای روزمره گردد. مطالعه حاضر با هدف بررسی یافته‌های تصویربرداری تشدید مغناطیسی در بیماران &rlm;مبتلا به میگرن &rlm;در &rlm;مقایسه با افراد بدون میگرن مراجعه کننده به بیمارستان علامه بهلول گناباد طراحی و &rlm;انجام شد. &rlm;</span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span style="tab-stops:446.5pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">مواد و روش‌ها: </span></span></span></b><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">مطالعه حاضر از نوع مورد شاهد بود که به بررسی 25 بیمار مبتلا به میگرن (گروه مورد) و 25 فرد بدون &rlm;میگرن که با استفاده از روش نمونه‌گیری در دسترس از بین مراجعه‌کنندگان به کلینیک مغز و اعصاب &rlm;بیمارستان علامه بهلول گنابادی در سال 1402-1401 انتخاب شدند، پرداخت. ابزار گردآوری داده‌ها در این &rlm;مطالعه چک لیست اطلاعات دموگرافیک، چک لیست معیارهای تشخیصی برای تعیین میگرن و انواع آن، چک &rlm;لیست ارزیابی شدت میگرن بر اساس مقیاس &rlm;</span></span></span><span dir="LTR" new="" roman="" style="font-family:" times="">MIGSEV</span> <span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">&rlm; و چک لیست علائم &rlm;</span></span></span><span dir="LTR" new="" roman="" style="font-family:" times="">MRI</span><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">&rlm; بود. داده‌ها با استفاده از &rlm;نرم افزار &rlm;</span></span></span><span dir="LTR" new="" roman="" style="font-family:" times="">SPSS</span><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">&rlm; نسخه 26 در سطح معنی داری کمتر &rlm;از 5 درصد مورد تجزیه و تحلیل قرار گرفت. &rlm;</span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span style="tab-stops:446.5pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">یافته‌ها: </span></span></span></b><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">میانگین سنی بیماران گروه مورد 34/35 (22/12) سال بوده و 76 درصد ایشان زن بودند. ارتباط معنادار میان تعداد پلاک و ابتلا به میگرن رویت شد و تعداد ضایعات (پلاک) مشاهده شده در گروه &rlm;مورد به صورت معنی داری بیشتر از افراد گروه شاهد بود (001/0&rlm;</span></span></span><span dir="LTR" new="" roman="" style="font-family:" times="">P=</span><span dir="LTR" lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">&lrm;</span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">&rlm;). بیشترین ناحیه وجود پلاک نیز ابتدا &rlm;لوب پاریتال و بعد لوب فرونتال بود. نتیجه آزمون دقیق نشان دهنده عدم تفاوت معنی دار دو گروه از نظر &rlm;لوب محل ضایعات بود (001/0&rlm;</span></span></span><span dir="LTR" new="" roman="" style="font-family:" times="">P=</span><span dir="LTR" lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">&lrm;</span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">&rlm;). تمام ضایعات مشاهده شده در دو گروه، در ماده سفید عمقی بود.&rlm;</span></span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span style="tab-stops:446.5pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">نتیجه‌گیری:</span></span></span></b> <span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">این مطالعه نشان داد که بیماران مبتلا به میگرن نسبت به افراد سالم، میزان بالاتری از ضایعات مغزی، به ‌ویژه در نواحی پاریتال و فرونتال، در ماده سفید عمقی دارند،. این یافته‌ها تأیید می‌کند که میگرن می‌تواند منجر به تغییرات ساختاری مغزی شود که از نظر بالینی دارای اهمیت هستند.</span></span></span><span lang="FA" style="font-size:14.0pt"><span style="line-height:115%"><span style="font-family:"Arial",sans-serif"></span></span></span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:11pt"><span style="line-height:115%"><span style="tab-stops:446.5pt"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Background and Objectives: </span></span></span></b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Headache and migraine disorders are among the most significant problems of the present era, which can lead to severe disabilities in daily activities. The present study was designed and conducted to investigate the findings of magnetic resonance imaging (MRI) in patients with migraine, compared to those without migraine who were referred to Allameh Bohlol Gonabadi Hospital in Gonabad, Iran.</span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span style="tab-stops:446.5pt"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Materials and Methods: </span></span></span></b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">This study followed the protocols of a case-control design, examining 25 patients with migraine (case group) and 25 individuals without migraine who were selected using convenience sampling from those referred to the Neurology Clinic of Allameh Bohlol Gonabadi Hospital (Gonabad, Iran) in 2022-2023. The data collection tools used in this study included a demographic information checklist, a checklist of diagnostic criteria for determining migraine and its types, a checklist for assessing migraine severity based on the Migraine Severity Scale, and a checklist of </span></span></span><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">MRI</span></span></span><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""> symptoms. The data were analyzed using SPSS software (version 26) at a significance level of less than 5%.</span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span style="tab-stops:446.5pt"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Results:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""> The mean (standard deviation) age of the studied medical staff was 35.34 (12.22) years, and 76% of them were females. In this study, the number of lesions (plaques) in patients with migraine (12 lesions) was significantly higher than that in the control group (1 lesion); using the appropriate statistical test, a significant difference was observed between the two groups (P=0.001), indicating a statistically significant relationship between the increase in the number of cerebral plaques and migraine. In terms of the site of lesions, the highest prevalence of plaques in patients with migraine was reported in the parietal lobe (8 lesions) and then in the frontal lobe (3 lesions), respectively. However, the difference in plaque distribution across different cerebral lobes between the two groups was not statistically significant (P=1.00). Additionally, examining the type of tissue involved revealed that all lesions observed in both groups were located in the deep white matter of the brain.</span></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:115%"><span style="tab-stops:446.5pt"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""> The number of brain lesions or plaques can provide a better understanding of changes in brain structure and function in patients with migraine and can be helpful not only in diagnosis, but also in selecting treatment and monitoring its effectiveness.</span></span></span></span></span></span></span></span> تصویربرداری تشدید مغناطیسی, میگرن, ضایعات ماده سفید مغزی, سردرد ‌ Magnetic resonance imaging (MRI), Migraine, Plaque 168 178 http://imtj.gmu.ac.ir/browse.php?a_code=A-10-3223-4&slc_lang=en&sid=1 Hanieh Shabani حانیه شبانی hanish9988@gmail.com 8000319475328460038464 8000319475328460038464 No Student of General Medicine, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran دانشگاه علوم پزشکی گناباد Fereydoon Moradi فریدون مرادی moradi@yahoo.com 8000319475328460038465 8000319475328460038465 No Neurologist, Allameh Bohlol Gonabadi Hospital, Gonabad University of Medical Sciences, Gonabad, Iran دانشگاه علوم پزشکی گناباد Fatemeh Mohammadzadeh فاطمه محمدزاده fmhz.uni@gmail.com 8000319475328460038466 8000319475328460038466 No Assistant Professor of Biostatistics, Department of Epidemiology and Biostatistics, Faculty of Health, Gonabad University of Medical Sciences, Gonabad, Iran دانشگاه علوم پزشکی گناباد Mohammad Keshtkar محمدرضا سبحانی sobhani24@yahoo.com 8000319475328460038467 8000319475328460038467 No Neurologist, 22 Bahman Hospital, Neyshabur University of Medical Sciences, Neyshabur, Iran دانشگاه علوم پزشکی نیشابور Mohammad Keshtkar محمد کشتکار keshtkar.dmohammad@yahoo.com 8000319475328460038468 8000319475328460038468 Yes Associate Professor of Medical Physics, Department of Medical Physics and Radiology, Faculty of Medicine, Infectious Diseases Research Center, Gonabad University of Medical Sciences, Gonabad, Iran دانشگاه علوم پزشکی گناباد