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Aims: Wound healing delay is a common complication of diabetes mellitus. Considering the antioxidant properties of the Launaea acanthodes, this study aimed to examine the effects of this plant on open skin wound healing in diabetic rats.

Materials & Methods: In this experimental study, 32 male rats were allocated into the equal groups of control, diabetic control and experimental diabetic 1 and 2. The diabetes in diabetic control and experimental diabetic groups was induced using an intraperitoneal injection of alloxan. In all samples, 4 wound with 7mm diameters were created in two lateral posterial parts of body. Then experimental diabetic groups 1 and 2 treated with 10 and 20% of Launaea acanthodes ointment and control and diabetic control groups treated with eucerin for 12 days. Histological studies were performed on each of the days 3, 6, 9 and 12. Data were analyzed by Kruskal-Wallis and post-hoc Tukey tests in SPSS 20 software.

Findings: The highest and lowest density of inflammatory cells in control group are 3^th and 12^th day, diabetic control 9^th and 3^th day, experimental diabetic 1 and 2 6^th and 12^th day. The highest and lowest thickness of the epithelium in control group are 6^th and 12^th day, diabetic control 12^th and 3^th day, experimental 1 9^th and 12^th day and experimental 2 6^th and 12^th day. The highest and lowest density of blood vessels in control group are 6^th and 12^th day, diabetic control 12^th and 3^th day, experimental 1 6^th and 3^th day and experimental 2 6^th and 12^th day.

Conclusion: Topical treatment of aqueous extract of Launaea acanthodes accelerates the healing of diabetic ulcers.

Keywords: Wound, Diabetes Mellitus, Skin, Rats
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