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Introduction: P53 is the most famous tumor suppressor gene that is mutated in over 50% of human cancers. This gene has been described as "guardian of the genome"," the guardian angel gene", and the " master watchman", referring to its critical role in genomic stability, and tumor suppression mainly by inducing apoptosis, cell cycle arrest, and senescence, inhibition of angiogenesis. In this review article were discussed recent advances in p53 research, mainly its role in apoptosis and the approaches to target p53 and its regulators for cancer treatment aimed to either to activate p53 in cancer cells to kill them or temporarily inactivation of p53 in the normal cells to protect them against chemo-radiation. Conclusion: Due to the vital roles of P53 in carcinogenesis inhibition, this protein is one of the most important therapeutic targets for cancer therapy. Based on genetic variation type in P53, in the normal and tumor cells, a combination of different therapies can be used and also by more comprehensive consideration of the involved signaling pathways new upstream and downstream novel proteins can be discovered to act as targets for new therapeutic targets.

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Introduction: Iranian traditional medicine dating back to 10,000 years ago was marginalized in the last 150 years, but physicians such as Dr. Ahmadieh has maintained and used it as a source of inspiration for the treatment of many diseases including melancholy. Melancholy, a then-type of depression, is a mental illness in which the person suffers from depression, isolation, hallucination, and delirium. This systematic review aimed to examine Dr. Ahmadieh’s views and experiences on melancholy treatment and compare them with Iranian traditional medicine literature. Materials and Methods: First, through a comprehensive search strategy, Dr. Ahmadieh’s books and the relevant Iranian traditional medicine literature were investigated and compared. Then, eight English and Persian databases, of Ovid MEDLINE, SciVerse Scopus, Google Scholar, ISC, MEDLIB, Magiran, Gang, and SID were searched by combining MeSH and non-MeSH term searches. Relevant studies were identified and retrieved after screening and the reference lists were carefully scanned. Finally, after extracting the data, the narrative synthesis of all results was performed in line with the objectives of the review. Results: Melancholy is one of the oldest terms in history of psychiatry that has been replaced with depression. In line with foundations of Iranian traditional medicine, Dr. Ahmadieh believes that increased or abnormal melancholy (black bile) is the cause of the melancholy. This disease has been classified into three groups, in accordance with DSM-5 criteria. Treatment of melancholy is based on six principles of health (including the nasal discharge stimulation and drainage, and relieving constipation) and its specific treatments are different depending on its class and cause. Conclusion: Dr. Ahmadieh’s experiences in treating diseases have the potential to be used as a complementary treatment or an alternative to standard treatments of conventional medicine, and worth being considered by researchers, clinicians, and health system policymakers. However, it is essential that the effectiveness of these traditional treatments be examined through reliable trials and be applied if they are evidence-based.

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Introduction: As a traditional treatment in many countries, the seeds of Nigella sativa are used to prevent and heal many diseases like diabetes, asthma, cough, nasal congestion, headache, toothache, intestinal worms, menstrual disorders, gastrointestinal diseases, and sexual dysfunction. The aim of this study was to review the published scientific reports about the physiologic effects of the seeds of Nigella sativa on different organs of body. In the review, scientific papers on the effects of the seeds of Nigella sativa on the functions of different organs of body, published between 1980 and 2015, were investigated and collected using Medline and SID databases.

Conclusion: Based on the laboratory studies, the seeds of Nigella sativa are with liver, kidney, gastrointestinal, nervous system, and cardiovascular protective effects, as well as anti-inflammatory, anti-cancer, anti-bacterial, and anti-parasite effects. Nigella sativa reduces blood pressure, blood sugar, and hyperlipidemia. Nevertheless, there are no expanded studies on the herb. No doubt, based on the results of laboratory studies and documents about its consumption administrated in the traditional medicine, it is useful to consume the herb in cases including a mild high blood pressure, as well as blood sugar increase and hyperlipidemia. However, it requires more human studies. 

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Introduction: In wide and developing worlds of cellular and particularly molecular sciences, the most important issue that leads to paying more attention to and use a technique, is its critical features; high sensivity, specificity, velocity and also being available and cheap. High Resolution Melting (HRM), may be one of these techniques. Its usage is growing among others significantly in investigations, for its special advantages. HRM is based on the pattern and characteristic of DNA when melting. DNA melting temperature (Tm), is the temperature that 50% of DNA molecules have become single stranded and 50% are double stranded. The pattern of getting single stranded is specific and unique for every DNA strand; and differences are shown as a graph called “melting curve". These are effective on DNA Tm: the value of bases G and C in both DNA strands (CG%), the length of fragment, the static effects of bases on each strand and the hetrozygocity. In fact, the differences among melting curves results in recognition the special fragment. The way of being single stranded can be followed by fleurcence colors which attached to double stranded DNAs.

Conclusion: High-resolution melting is powerful, fast, comprehensive and useful technique for using in molecular laboratory that can be considered as simple and fast approach for genotyping, mutation detection, matching sequence and methylation study.

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Aims: Angiogenesis and angiostasis processes mean the forming and preventing the formation of a new capillary from pre-capillary, respectively. Angiogenesis due to exercise is controlled by the balance between angiogenic and angiostatic factors. Angiogenesis due to exercise training by increasing capillary density in muscle fibers improves the transfer of oxygen and nutrients to the muscle. The aim of this review was to evaluate the response of each of these angiogenic and angiostatic factors to exercise.
Conclusion: Vascular endothelial growth factor, transforming growth factor-β, angiopoiten and matrix metalloproteinase are most important angiogenic factors that show an up-regulated response following exercise. In contrast, angiostatin, endostatin, thrombospondine 1, and tissue inhibitor of metalloproteinase act as most important angiostatic factors. Although their functions in cell culture are cleared, further research is still necessary to obtain more consistent conclusions about response of inhibiting factors in both of physiologic and pathologic conditions following exercise.
 
 

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Aims Breast cancer is among the most prevalent cancers in women and has mental and emotional effects, leading to declined quality of life. The current this study aimed to determine the prevalence rate of depression in Iranian women with breast cancer.
Methods & Materials This study was conducted using a meta-analysis method at Zabol University of Medical Science in March 2019. Six electronic databases were searched and evaluated for original research papers published on the prevalence of depression in Iranian women with breast cancer. Finally, 15 articles were selected and analysed using Comprehensive Meta-Analysis software.
Findings Overall, the prevalence rate of depression in Iranian women with breast cancer was 18.5% (95% CI: 14.2%-23.7%). The highest reported prevalence of depression in Iranian women with breast cancer was 35% in Babol City, in 2013, (95% CI: 27.8%-43%); the lowest prevalence of depression in this population was measured as 3.4% in Qom City, in 2017 (95% CI:1.2%-9%). A significant correlation was observed between the prevalence rate of depression, and sample size, year, and mean age (P<0.05).
Conclusion Depression affects approximately one-fifth of women with breast cancer. Therefore, it is essential for the healthcare staff to treat the physical conditions and psychological disorders associated with breast cancer.

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Aims: Cronobacter sakazakii (CS) is a member of the Enterobacteriaceae family. It is a genomically heterogeneous, motile, Gram-negative bacillus. It is also an emergent foodborne pathogen associated with the ingestion of infant formula milk that can cause neonatal sepsis, necrotizing enterocolitis, and meningitis. This review is focused on the newest information about the bacterial characteristics of C. sakazakii and human infections causing by this pathogenic bacterium. 
Methods & Materials: We searched medical databases such as ISI Web of Science, PubMed, Scopus, and other websites. 
Findings: Cronobacter sakazakii acts as a microbiological hazard in the infant food chain, with historic high mortality in neonates. The International Commission for Microbiological Specifications for Foods has categorized C. sakazakii as a severe hazard bacterium for some individuals, with long duration, substantial chronic sequelae, or life-threatening complications. Although the incidence of C. sakazakii infection is low, the prognosis of the disease is poor, and infection is associated with significant morbidity and mortality. Powdered Infant Formula (PIF) milk products contaminated with C. sakazakii have been epidemiologically linked to several clinical cases. Premature infants, low-birth-weight ones, and patients hospitalized in the Neonatal Intensive Care Units (NICUs) are more at infection risk than older infants.
Conclusion: We recommend focusing on simple preventative strategies such as the promotion of breast milk feeding, the inclusion of warnings on the powder infant formula packages that may be contaminated with C. sakazakii, and abstinence from the practice of re-warming of reconstituted formula. Reconstituted dairy products should be avoided in adult immunosuppressed populations. Appropriate barrier precautions should be observed in NICU and intensive care unit settings, where the spread of infection may be more prevalent. 

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Aims: The number of pediatric dental clients is on the rise. Besides, the relevant methods are costly and concerning; therefore, psychological methods are required to treat pediatric dental anxiety. The current study aimed to evaluate the effects of the Coping Cat Program (CCP) on anxiety, Emotion Regulation (ER), and resilience among 7- to 12-year-old children. 
Methods & Materials: This was a case study with multiple baselines and a one-month follow-up design. The research sample included 4 subjects referring to the dental clinic in Mashhad City, Iran, in May 2017. The study participants were selected by the purposive sampling method. The study subjects received 16 therapy sessions (2 weekly sessions) based on the CCP. The child version of the Cognitive Emotion Regulation Questionnaire (CERQ-k) and Spence Children’s Anxiety Scale-Child (SCAS-Child) were used to collecting the required data. For data analysis, the graphical analysis method and the determination of recovery percentage were applied. The obtained data were analyzed using SPSS v. 21.
Findings: Anxiety scores in the pretest and posttest in the first child ranged from 62 to 44 with the recovery rate of 0.29; in the second child, it ranged from 57 to 37, with a recovery rate of 0.35; in the third child, it ranged from 48 to 35, with a recovery rate of 0.27, and in the fourth child, this rate decreased from 55 to 25 with a recovery rate of 0.54. Resilience scores in the pretest and posttest in the first child ranged from 52 to 75, with a recovery rate of 0.44, in the second child, it was from 43 to 66, with a recovery rate of 0.53; in the third child, it ranged from 58 to 74, with a recovery rate of 0.27, and in the fourth child, it increased from 64 to 89, with a recovery rate of 0.39. ER components also significantly improved in the examined children.
Conclusion: The present study data indicated that CCP was effective in reducing anxiety symptoms as well as increasing ER and resilience among children aged 7 to 12 years referring to dentistry. Thus, this method can be used to reduce anxiety symptoms and increase ER and resilience in this population. This method helps the child to become aware of negative thoughts, find evidence respecting their negative thoughts, cope with anxiety, learn skills, and practice and repeat these skills. 

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On 12 December 2019, a new Severe Acute Respiratory Syndrome Coronavirus-2 (Sars-Cov-2) was reported in Wuhan, China, causing the outbreak of Coronavirus Disease 2019 (COVID-19). On 25 January, 2021, the number of COVID-19 deaths worldwide reached 2 million and the number of confirmed cases reached more than 100 million. The COVID-19 pandemic has had a profound effect on human health and has caused sudden changes with social and economic consequences in human lifestyle due to social distancing and staying at home. Improving public health during this pandemic requires to have knowledge of medical and biological concepts, as well all concepts related to lifestyle and social and behavioral acts, including eating habits. One of the methods to strengthen the immune system against COVID-19 is to modify nutrition and have proper dieter regimen. This study aims to review the role of nutrition during the COVID-19 pandemic and present recommendations for improving nutritional health at this period.

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Aims: Nowadays, herbal medicine is commonly used due to the side effects and high costs of chemical medicines. Cinnamon appears to be effective in the prevention and treatment of a variety of diseases, which is used in both food industry and traditional medicine. This study aims to review the effects of cinnamon on the occurrence of cardiovascular diseases and their related risk factors. 
Methods & Materials: In this review study, the search was conducted using the keywords in English including Cinnamon, Cinnamomum, Cinnamaldehyde and Heart, Cardiac, and Cardiomyopathy based on MeSH terms and the keywords in Persian for the related articles in Web of Sciences, PubMed, ScienceDirect, Scopus, Google Scholar, and Scientific Information Database (SID) databases published until March 2021. Out of 205 studies, 51 experimental and clinical human and animal studies were reviewed.
Findings: The results of studies reported the effects of cinnamon on the risk factors of cardiovascular diseases such as hyperlipidemia, hypertension and oxidative stress.
Conclusion: The majority of human and animal studies have shown that cinnamon prevent and treat cardiovascular diseases by lowering oxidative stress and improving blood pressure and blood lipid parameters. 

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Aims The current study was conducted to investigate the effectiveness of psychological interventions (mental-educational) on the quality of sleep among patients with chronic diseases in Iran during 2003-2021.
Methods & Materials The current study is a meta-analysis in terms of purpose. The population included all master’s and PhD. dissertations and theses, studies published in scientific journals, and studies published by Iranian authors living abroad. The instrument applied for the analysis of the data was the meta-analysis checklist, and the stages of the meta-analysis were conducted according to the technique proposed by Howitt and Cramer (2005).
Findings After investigating 57 studies, 31 studies including 1813 participants were found to meet the entry criteria. The results showed that the total effect size is 0.99. The compound level of significance related to the studies was found to be P<0.0001, which indicated the significance of the total effect sizes obtained in the psychological studies on the quality of sleep among patients with chronic diseases.
Conclusion The effect size of the psychological interventions conducted on the quality of sleep among patients with chronic diseases in Iran is high according to Cohen’s table. Hence, implementing this novel therapeutic approach can be considered an effective method in the enhancement of the quality of sleep in patients with chronic physical disease.

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Aims: Type 2 diabetes is a chronic disease, which lowers the life expectancy of its sufferers due to some problems. Mitochondrial dysfunction is a prominent feature in type 2 diabetes. MOTS-C is a mitochondrial-derived peptide with sports-mimicking activity that has beneficial effects on metabolism and exercise capacity. The purpose of this article is to review the performance of MOTS-c peptide and the mechanism of action of exercise training on the improvement of type 2 diabetes.
Materials and methods: This review study, by searching in the articles available in the databases, Scapus, Google scholar, Pubmed and Farsi including,   Magira and with the keywords MOTS-c, type 2 diabetes, sports training related to the years 1991 to 2022 was done. The search was limited to articles in English and Farsi whose full text was available. In general, among the 52 articles obtained, 41 articles whose full text was available were examined.
Findings: and conclusions: Exercise training increases the MOTS-c level and MOTS-C activates AMPK in skeletal muscles and improves the energy metabolism.
Conclusion:Exercise training improves insulin sensitivity, reducing the risk of concomitant diseases.


 

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