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Background and Aim: Cardiac autonomic neuropathy (CAN) is one of diabetes micro-vascular complications associated with increased cardiovascular mortality. CAN is more frequent in patients with other diabetes micro-vascular complications. In this research we evaluated the relation between CAN and other diabetes micro-vascular complications. Materials and Methods: This research includes 41diabetic patients (25 female and 16 male with mean age of 44.9 yr and 8.6 yr of history of diabetes) who had regular evaluation in Kashan Diabetes center. All of them assessed for diabetes micro-vascular complications and CAN. Results: There wasn’t any meaningful statistical relationship between CAN and diabetic sensory neuropathy, retinopathy and nephropathy. Sensory neuropathy was the most frequent diabetic micro-vascular complications associated with CAN (71%). There wasn’t any evidence of CAN in 31% of the patients with sensory neuropathy while CAN had founded without sensory neuropathy in 21% of these patients. Conclusion: There wasn’t strong statistical correlation between CAN and other diabetic microvascular complications. Diabetic patients should be evaluated for CAN because it can’t be rule out in the absence of other microvascular complications.

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Aims: One of the most prevalent mitochondrial genetic diseases is Leber disease. Most of the patients are with the bilateral ocular involvement, simultaneously in 25% and one after another in 75% of the patients with an average of 8-week involvement distance between two eyes. The aim of the study was to report a rare case of Leber disease with 11-year engagement distance between two eyes.  

Patient Profile: A 38 years old male patient, who had been hospitalized in autumn 2012 in Beheshti Hospital in Kashan, Iran, due to his left-eye vision loss, was studied. One day before referring to the hospital, his left-eye vision had gradually blurred, only could perceive light. The patient were with HBs Ag positive (Carrier), and was hypertensive from about one year before hospitalization. Based on the ophthalmoscopy results, the right-eye disc was lost and the left-eye disc was pale.

Findings: At first, the patient received methylprednisolone pulse therapy, while no treatment response was observed after a 2-week therapy. Based on the genetic assessments of peripheral blood cells, the homoplastic 14233 mutation was diagnosed, confirming the clinical suspicion of Leber disease (LHON). The patient received 100mg a day Q10 coenzyme and multivitamin.

Conclusion: The diagnosis of Leber hereditary optic neuropathy should be noticed in young men with bilateral optic atrophy.