N. Khodakrami, Dr. F. Moatar, Dr. A. Ghahiri, Volume 14, Issue 2 (vol-2 2008)
Abstract
Background and Aim: To study the effect of an Iranian herbal drug in the treatment of primary dysmenorrhoea a randomized, double-blind, placebo-controlled pilot trial among 180 female students settled at Isfahan University dormitory aged 18–27 years who suffered from primary dysmenorrhoea was conducted.
Materials and Methods: Participants were divided into three groups randomly (herbal drug, mefenamic acid and placebo). The herbal drug (Saffron, Celery See and Anise extracts highly purified) group was given 500 mg of SCA three times a day for three days, starting from the onset of bleeding or pain was administered. Participants were followed with three cycles from beginning of menstruation and continued through the whole three days of bleeding. Main outcome measures the severity and duration of pain at two and three months. A visual analogue scale was used to record pain. Overall-pain was the average pain intensity among days in pain.
Results: There were statistically significant reductions in pain score and pain duration in SCA (p<0.01) and mefenamic acid (p<0.01) groups. The decrease in pain score was reflected by a significant reduction in another drug used among the treatment groups compared with placebo. The magnitude of the reduction was significantly greater in the SCA group than in mefenamic acid and placebo (p=0.031).
Conclusion: Both of the drugs relieved menstrual pain effectively in compare with placebo. So more clinical trials are need for efficacy of this herbal drug.
Reihaneh Radmanesh, Mohsen Nabi Meybodi, Vahid Ramezani, Maryam Akrami, Mohammad Ali Ranjbar, Azadeh Emami, Volume 26, Issue 1 (Winter 2019)
Abstract
Aims: Any pharmaceutical product made in pharmacy, hospital or factory may be contaminated with microbes. This contamination can originate from raw materials or during production. Hence, it is important to study the physical and chemical properties and stability of compounded drugs. Methods & Materials: In this study, first a specific sample of prescribed medication was ordered from 63 pharmacies in Yazd, Iran. After collecting the samples, the amount of microbial contamination, viscosity and particle size distribution and their stability were investigated and their results were compared to the standard levels. Findings: Based on the results, 31.7% of the samples had discoloration and 23.8% showed creaming phenomenon. In terms of particle size distribution, 57.1% of the samples had a 20-40 μm particle size and 49.2% had a viscosity equal to 2500-3000 centipoise. Regarding stability, 12.6% of the samples underwnet phase change at 30-40°C. About of the amount of hydroquinone in samples, 35% had acceptable amount. In 23.8% of the samples, fungal infection was observed. Conclusion: Contrary to a popular belief that the compounded medicines produced in pharmacies have microbial contamination, the results of this study showed that the microbial contamination of these compounded medications is low.
