Dr. Valialah Dabidi Roshan, Mr. Yousef Hemmati Safarshahi, Mr. Haji Ghorban Nooredinini,
Volume 18, Issue 2 (7-2012)
Abstract
Background and Aim: Some studies have shown the detrimental effect of lead on bone mineral density. We investigated the interactive effects of exercise and turmeric extract on the regional bone mineral density of femur bone in rats exposed to lead acetate.
Materials and Methods: In an experimental study, 50 rats were randomly assigned to groups Lead acetate, Exercise+lead, Turmeric Supplementation+lead , Exercise+Turmeric+Lead and control (Sham-operate) group. Rats received lead acetate (20 mg/kg) and/or turmeric extract (30 mg/kg), 3 days in a week for 8 weeks. Endurance exercise was performed 5 days a week, with progressive speed and time. The data of BMD and the other variables were analyzed by using SPSS software version 16 employing one-way ANOVA at P≤ 0.05 level.
Results: MDA and TAC concentrations were significantly lower and higher in the exercise, turmeric and the exercise+turmeric groups, compared with lead group, respectively. In addition, endurance exercise and/or training+turmeric not only led to decrease in lead-induced BMD levels, but also resulted in a significant increase in BMD levels, in particular, femur and distal epiphysis regions compared with lead and sham groups.
Conclusion: The lifestyle such as exercise training and antioxidant supplementation can offer beneficial effects for preventing loss Lead-induced administration in femur BMD, in particular, in regions with spongy bony tissue.
Zahra Ghorbani Shorkaii , Valiollah Dabidi Roshan ,
Volume 19, Issue 4 (1-2014)
Abstract
Aims: Growth factors are associated with a change in body composition and chronic diseases such as cancer. The aim of this study was to determine the individual and concomitant effect of water-based exercise and oral Zingiber officinale supplement on Changes in growth factors and estrogen in overweight women with breast cancer.
Methods: In a semi-experimental study, Forty obese women diagnosed with breast cancer(76±9 kg, fat mass 41.8±4 percent) participated. Subjects were randomly assigned into groups placebo, water-based exercise, Zingiber and water-based exercise+Zingiber groups. Subjects in the Zingiber group and combined group orally received 4 capsules contained 750 mg of zingiber flour for 6 weeks. The water-based exercise program were collected at a progressive intensity and time, ranged from 50 to 75 percent of heart rate reserve, for 6 weeks. Fasting blood sampling was collected at the pretest and post-test.
Results: Although, the Zingiber and or the water-base exercise resulted in a reduction in IGF-1 and estrogen levels and a increase in IGFBP-3 levels, changes in the index following the combined intervention (exercise in water+Ginger supplements) were more pronounced compared with pre-test and the control group. However, there was the significant difference only in IGFBP-3 levels between water-base exercise and Zingiber supplementation groups (p=0.046).
Conclusion: Our findings indicate a protective effect of the nondrug strategies such as exercise in water and anti-inflammatory herbal factors in the pathogenesis of growth and metabolic responses in overweight women diagnosed with breast cancer.
