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Showing 4 results for Osteoarthritis
Effect of Grade 1 Mobilization of Patellofemoral Joint on Reducing Pain and Joint Stiffness and Improving Physical Function in Patients with Knee Osteoarthritis
Mr. Mahdi Tavakkoli, Mr. Farid Bahrpyma,
Volume 16, Issue 1 (4-2010)
Abstract
Background and Aim: Knee osteoarthritis is one of the most common disabilities and has caused a lot of limitations in human. There are many methods proposed for its treatment. The aim of this study was to assess the effect of grade one mobilization of patellofemoral joint on reducing the pain and joint stiffness and improving the physical function in knee osteoarthritis patients. Materials and Methods: This study was one side blind clinical trial which was carried out in physical therapy department of Sarcheshmeh copper town polyclinic. The patients were selected randomly. Outcome instrument was WOMAC index (sum of data resulted from WOMAC questionnaire form) and measurements were done before and after treatment nearly one week after final treatment session. 30 patients with diagnosis of knee osteoarthritis, grade two or three, were divided into 3 groups randomly: Group 1: Mobilization + Exercise therapy, Group 2: Exercise therapy and Group 3: Mobilization. The ultrasound with the intensity below 0.2 w/cm2 in three minutes was used for all groups as placebo. The duration of treatment was 10 sessions for 3 weeks. To analyze the data, nonparametric tests were used at the significance level of 0.05. Results: In group one, WOMAC index decreased from 61.5+9.69 before treatment to 49.7+11.88 after treatment (P=0.005). In group two, WOMAC index decreased from 56.7+17.24 before treatment to 45.2+19.90 after treatment (p=0.022), and in group three, WOMAC index decreased from 59.6+16.51 before treatment to 47.7+19.72 after treatment (p=0.059). The difference of WOMAC index at the follow-up session, in comparison with the one before treatment, was significant only in group one which decreased to 50.1+11.73 (p=0.005). Conclusion: This study showed that grade 1 mobilization of patellofemoral joint can cause the effect of exercise therapy on reducing the pain and joint stiffness and improving the physical function in patients with grade 2 or 3 knee osteoarthritis continue at least for about one week.
Standing Stability in Knee Osteoarthritis Patients
M.t. Karimi, A. Esrafilian, M. Salahi ,
Volume 22, Issue 3 (6-2016)
Abstract

Aims: Being prevalent in the more than 40 years old persons, the knee osteoarthritis is one of the main factors in the function system failure mainly affecting their life. There is a type of instability in the persons with knee osteoarthritis, which is an increase in the domain and frequency of body pressure center. The aim of the present study was to compare the standing stability parameters in persons with knee osteoarthritis and healthy persons.   

Instrument & Methods: In this case-control, 15 patients with knee osteoarthritis referred to the physiotherapy clinic of the rehabilitation center and Al-Zahra hospital were studied in the muscle-skeletal research center of Isfahan University of Medical Sciences in 2015. The subjects were selected via stratified sampling method. As control group, 15 healthy persons were also studied in Isfahan. Total path length and the domain and frequency of pressure center in different directions were measured to assess the stability. Data was analyzed by SPSS 19 software using descriptive statistics and paired T test.

Findings: There were increases in the mean movement domain and the frequency of pressure center in the anterior-posterior and the internal-external directions, as well as in the total path proceeded by the pressure center in the internal-external direction, in the persons with knee osteoarthritis than the healthy persons (p<0.05). Nevertheless, there was no significant difference in the mean total path proceeded by the pressure center in the anterior-posterior direction (p>0.05).

Conclusion: Standing stability and balance in persons with knee osteoarthritis decreases compared to healthy persons.


Comparing Relative Contrast in Three-dimensional Double-echo Steady State With Routine Sequences for a Better Diagnosis of Knee Cartilage Anomalies
Sepehr Lotfi Marangaloo, Amir Shahriar Ariamanesh, Behzad Aminzadeh, Hormoz Abedi, Alireza Montazerabadi,
Volume 26, Issue 2 (3-2020)
Abstract
Aims This study compared relative contrast values in three-dimensional Double Echo Steady State (DESS) sequences with two flip angles of 40 and 90 degrees and other routine sequences. The obtained data could help to prove the effects of this sequence, compared to the other routine sequences; accordingly, it could be applied for better detection of lesions resulting from cartilage abnormalities.
Methods & Materials Total, 15 patients, including 9 men (14-56 y) and 6 women (36-65 y) with knee pain symptoms were referred to us by an orthopedic physician. All of the investigated patients underwent Magnetic Resonance Imaging (MRI) using DESS sequences with two flip angles of 40 and 90 degrees, as well as STIR , PD, T2, and 3D FLASH. We analyzed the acquired images using the Radiant DICOM Viewer4.6.9 software. We calculated relative contrast values for the selected SAGITAL images per sequence for each patient. The obtained data were analyzed using SPSS.
Findings Friedman and Wilcoxon statistical tests data revealed significant P values (<0.05) for all the sequences examined in this study. The DESS sequence with a flip angle of 90° presented the most relative contrast value with the average score of 77.2667. The FLASH sequence provided the worst result of 3.733 for the relative contrast value.
Conclusion The DESS sequence with 90° flip angle indicated the best relative contrast values and provided the best possible signal from the synovial fluid and the cartilage; therefore, it leads to the better examination of articular cartilage in terms of lesion. Accordingly, the DESS sequence with a flip angle of 90° was the optimal sequence to evaluate cartilage abnormalities among the examined sequences in this study.

Effect of Three Therapeutic Methods of Exercise, Ozone, and Stem Cells on the MEF2C Expression and Myostatin Levels in Femoral Muscle Tissue of the Osteoarthritis Rats
Zahra Haddadpour, Hajar Abbaszadeh, Parvin Farzanegi,
Volume 26, Issue 3 (6-2020)
Abstract
Aims: Myostatin and Myocyte Enhancer Factor 2C (MEF2C) are involved in muscle changes associated with bone problems. The aim of the present study was to determine the effect of three therapeutic methods of exercise, ozone, and stem cells on MEF-2C gene expression and myostatin levels of femoral muscle tissue in osteoarthritis rats.
Methods & Materials: This experimental study was done on 63 male rats (mean age of 8-12 weeks and weight of 250-300 g). They were randomly divided into nine groups: the healthy control and osteoarthritis group and seven intervention groups of osteoarthritis rats, including , saline, exercise, ozone therapy, MSCs, MSCs+ozone therapy, exercise+ozone therapy, and exercise+MSCs. Osteoarthritis was induced in rats by surgery. The training program consisted of 30 min of running on a non-slip treadmill at a speed of 16 m/min. Rats in the MSCs group received 1×106 cells/kg. The ozone was injected into the articular line of the knee tibiofemoral at a concentration of 20 μg/mL. Tissue levels of myostatin were measured by enzyme-linked immunosorbent assay kits and MEF2C gene expression was measured by real-time polymerase chain reaction method. 
Findings: Cell+exercise, exercise+ozone, and cell+ozone groups showed a significant increase in MEF2C gene expression and a significant decrease in myostatin levels compared with the cell, exercise, and ozone groups (P<0.05). In the exercise+cell group, these changes were greater.
Conclusion: The results showed that the combination of exercise and MSCs with an increase in MEF2C gene expression and a decrease in myostatin levels, can possibly have beneficial effects on the stimulatory and inhibitory factors of interactions between muscle and bone in the osteoarthritis rats, and ultimately reduce the risks of muscle weakness due to osteoarthritis complications.

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