Showing 10 results for تومور
Dr. M. Faraji Rad, Dr. Mr. Ehsaee, A. Ehsaee, Dr. E. Ghayour Karimiani,
Volume 10, Issue 2 (7-2004)
Abstract
Background and Aim: Early diagnosis of brain tumors according to ocular symptoms is important considering the fact that sometimes ocular finding is the first presentation. The purpose of the present study was to investigate ocular findings in patients with brain tumors.
Materials and Methods: In this retrospective study 100 patients with documented brain tumors that were operated on in Ghaem Hospital, Neurosurgery Department, were reviewed and the ocular findings were analyzed statistically.
Results: Out of 100 patients, 41 were male and 59 were female with the mean age of 32 years. Bilateral papilledema in 56%, unilateral papilledema in 9%, visual field effect in 14%, unilateral optic disc atrophy in 15%, petosis in 2%, proptosis in 3%, six nerve palsy in 12% and third nerve palsy in 3% of cases were found.
Conclusion: Due to the fact that ocular findings are sometimes the first symptom to occur in patients with brain tumors and these patients may refer to an ophthalmologist or optometrist so early diagnosis and referral to a neurosurgeon can be helpful.
Dr. Ar. Khooei, Dr. R. Taghavi, Dr. Mr. Keramati,
Volume 10, Issue 3 (10-2004)
Abstract
Juxtaglomerular cell tumor or reninoma is an extremely rare tumor of the kidney, specially occurring in the young adults. This tumor by producing rennin and activating the Renin-Angiotansin- Aldostrone pathway causes an increase in blood pressure associated with hypokalemic metabolic alkalosis. We report a young female patient, aged 18 years, presented with hypertension, as the chief complain, and associated hypokalemia. CT-Scan and sonography showed a renal mass diagnosed as renal cell carcinoma or pheochromocytoma. In the nephrectomy specimen there was a tumor measuring 4.5*3.5 cm, creamy to brownish color limited to the renal capsule. Microscopic examination revealed an encapsulated tumor composed of sheets of round to polyhedral cells in a vascular stroma with slight atypia and without mitoses or necrosis, finally diagnosed as juxtaglomerular cell tumor. Microscopic features and clinical course are discussed with reviewing the literatures. Because of the rarity of this neoplasm we highly emphasize reninoma should always be considered as a probable cause in a young adult with hypertension.
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Volume 11, Issue 4 (1-2006)
Abstract
Background and Aim: Bone tumors are relatively common neoplasms composed of malignant, benign and intermediate varieties of which three groups are very important due to diagnostic, treatment and basic scientific aspects : 1- Tumors with unknown origin including giant cell tumor and Ewing’s sarcoma. 2- Unusual bone tumors including adipose, muscular and neural tissue tumors. 3- Bone metastases which are included in differential diagnosis of many primary bone tumors specially when their origin is not clinically detectable. The aim of this research is first to determine the role of new diagnostic methods specially immunohistochemistry staining in diagnosis and typing of these tumors and to compare the results with conventional microscopy for documenting more accurate diagnostis criteria, and second to compare their clinicoepidemiologic, radiologic and pathologic charecterstics with other world wide reports and third to achive more experience in routin microscopic diagnosis of these tumors.
Materials and Methods: All tissue specimens archived in pathology department of Mashhad Emam Reza Hospital in last 30 years were evaluated. Among the 126670 filed specimens, 163 cases previously diagnosed as any one of these three groups were specified and elicited. Registered epidemioclinical and pathologic informations were gathered and organized in tables. Then microscopic slides were reviewed applying new diagnostic criteria, and if necessary further sections for conventional H/E and histochemical study were obtained and specially immunohistochemical assesment with appropriate markers was performed.
Results: From 163 elicited tissue specimens, 2 cases due to unrelated final histopathologic diagnoses and 5 cases because of their specification as soft tissue tumors, were rulled out. Tumors with unknown origin composed 61.5%, unusual bone tumors about 2% and bone metastases 36.5% of the documented studied tumors. In most cases the diagnostic, radiologic and pathologic charectristics were in correspondance with classical features of these tumors and other world wide reports. Merely 13% of the cases required immunohistochemical study for definite diagnosis, of which only in 4 cases the microscopic diagnosis changed.
Conclusions : Conventional microscopic diagnostic method with carefull attention to clinical and radiologic findings is the main method for diagnosing these tumors, of course in few complicated cases complemental procedures such as immunohistochemistry is inevitable in diagnosing and determining accurated and true nature of these bone tumors.
Dr. M. Farzadnia, Dr. N. Tayebi-Meybodi, Dr. S. Amooeian, Dr. M. Mehrabi, Dr. F. Heidari,
Volume 12, Issue 1 (4-2006)
Abstract
Abstract
Insulinoma are the most common islet cell tumors and located almost exclusively in the pancreas. Most of these tumors are sporadic, they may also be associated with the multiple endocrine neoplasia type 1 syndrome (MEN1). More than 90% of insulinomas are benign. Preoperative radiographic localization may prove difficult. Intraoperative palpation and ultrasound remain the gold standard for detection. A 27 years male presented with history of intermitent fainting attacks, headache ,loss of consciousness and increased body weight. his fasting blood sugar was 40 mg/dl and insulin glucose ratio was 0.57-0.76. CT Scan of abdomen did not show tumour in pancreas.Laparotomy was done and tomour in head of pancras was removed .according to clinical and microscopic finding The tamour was found to be a insulinoma.. the aim of this study is recognition of this rare tumor and diagnosis with laboratory methods.
Dr. H Mashhadi Nejad, Dr. F Samini, Prof. H Rezvani,
Volume 12, Issue 2 (7-2006)
Abstract
Background and Aim: This study has been achieved to establish the indications of surgical intervention at the appropriate gestational duration for brain and medullary tumors in pregnant women and to evaluate any correlation between gestational hormones and the rate of occurring or rate of growth of brain or medullary tumors.
Materials and Methods: In our retrospective study since 1999 to 2005, 1027 patients who had been admitted and operated in neurosurgical centers were determined. The female patients who were in fertility age were selected and statistical analysis with descriptive methods and Chi-Square test was done in patients who had intracranial or intraspinal tumors or their neurological findings were accelerated. Then we compared our results with other studies.
Results: From 1027 patients in our study with brain or medullary tumors, 23 patients were pregnant. 17 cases had intracranial and 6 cases had intraspinal tumors. 52.9% of brain tumors and 50% of intraspinal tumors in our study were meningioma. Most of patients in our study were operated after delivery and results were good in almost all of patients.
Conclusion: A decision for best management and treatment is different in pregnant patients with intracranial or intraspinal tumors. This study indicated that the rate of intracranial and intraspinal tumors, specially meningioma, or accelerated rate of neurological findings are probably because of hormonal receptors specially progesterone receptors. If the patient’s condition worsens, the tumor should be excised as soon as possible but if the neurological condition of patients is stable, it would be rather the operation is achieved after delivery.
Dr. A. Khooei, Dr. F. Farhadi,
Volume 12, Issue 4 (1-2007)
Abstract
Background and Aim: Cutaneous appendages give rise to various types of neoplasms which generally according to embryologic and histologic features are divided to pilocebaceous and sweet- gland tumors. Sebaceous tumors are a subgroup of the former that the accurate diagnosis of them is very important. Some of these tumors not only can be malignant and life threatening but also have many common and overlapping histologic features with some other benign and malignant cutaneous tumors that sometimes make them difficult to be diagnosed accurately. In addition, these tumors may be an alarm for an internal malignancy. The purpose of this study is to asses clinicoepidemiologic features of sebaceous tumors and histopathologically review and reclassify them by applying the new diagnostic criteria.
Materials and Methods: Among 134748 archived tissue samples during a thirty-year period (1976-2005) In pathology department of Emam Reza University Hospital in Mashhad, all tissue specimen with a definite, probable, differential or uncertain diagnosis of any kind of sebaceous tumors were elicited. If necessary, new slides with conventional and special histochemical stains were prepared. All tissue slides were restudied, clinical data were gathered and presented in charts and tables and finally analyzed statically.
Results: Previous histopathologic diagnosis in 116 sebaceous tumors were confirmed, in 3 lesions, the diagnosis changed and 5 cases were excluded. 73 patients were men and 43 were women with a mean age of 34 year. These tumors included 66 nevus sebaceous, 24 sebaceous hyperplasia, 1 folliculo-sebaceous cystic hamartoma and 24 sebaceous carcinoma. In most instances previous pathologic diagnosis were correct and clinicoepidemiologic features were in accordance with other worldwide reported cases, although some considerable mistakes in previous diagnosis and differences in clinicoepidemiologic features were noted.
Conclusion: Sebaceous tumors are relatively uncommon tumors mostly benign, occruing in both sexes in a broad range of age. Regional geographic and lesional differences may be observed in pattern of involvement. For an accurate diagnosis, the pathologist must pay special attention to the wide range of differential diagnosis and to apply definite histopathologic criteria regarding differences in pattern of involvement.
Dr Mt. Peivandi, Dr Mh. Ebrahimzadeh, Dr Hasani M.,
Volume 14, Issue 3 (10-2008)
Abstract
We present a rare case of intramuscular Haemangioma of the forearm with periosteal reaction of radius and ulna. A 38-year-old female presented with a tumefaction in distal and dorsoulnar side of the right forearm. She had 1.5 years history of tumor which was painful during resent 2 months. Plain x-ray and MRI was done and the diagnosis of Haemangioma was proved by open biopsy. The tumor plus periosteal reaction and enlarged bone was respected. After 4 years follow-up no recurrence was seen.
Azemati M., Shaker Hosseini R., Hekmatdoost A., Hosseini M.,
Volume 19, Issue 3 (9-2013)
Abstract
Aims: Long-chain omega-3 fatty acids consumed through diet reduces the production of IL-1, IL-6, IL-4, TNF-α by different cells. Osteoporosis increases the risk of bone fractures, particularly in postmenopausal women . The aim of this study was to investigate the effects of canola in comparison to sunflower oil on serum inflammation markers in patients with osteoporosis.
Methods: In a randomized clinical trial, 40 osteoporotic of bone disease center of Shahid Beheshti University of Medical Sciences were selected by available sampling from September 2010 to November 2012. The patients were divided into two groups of canola and sunflower oil. The data were analyzed by SPSS 16 software by coupled and independent T tests.
Results: In sunflower oil group, systolic blood pressure reduced significantly (p=0.001). Serum vitamin D3 was also increased significantly in canola (p=0.03) and sunflower oil groups (p=0.042) at the end of the intervention period in comparison to baseline. Changes of IL-1, IL-4, IL-6, TNF-α level were not significant in the end of the intervention period in comparison to baseline in both groups.
Conclusion: The consumption of canola in comparison to sunflower oil, do not have any effect on reduction of inflammatory biomarkers in osteoporosic.
Ghodratollah Maddah, Abbas Abdollahi, Mehrangize Khajeh Karamadini, Solmaz Nakhaeizadeh, Azadeh Jabbari Noughabi, Ali Jangjoo, Hossien Shabahang, Mina Alvandipour,
Volume 19, Issue 4 (1-2014)
Abstract
Aims: Gastric adenocarcinoma is one of the most common cancers worldwide. Most epidemiological studies have indicated the role of H. pylori infection on increased risk of gastric adenocarcinoma. The aim of the present study was to investigate the presence of this microorganism in gastric cancer in different regions of the stomach and to compare it with non malignant lesions.
Methods: Samples were obtained from 50 confirmed cases of gastric adenocarcinoma who underwent gastrectomy during the years of 2007- 2008 at Ghaem and Omid hospitals of Mashhad. Gastric tissue of 50 patients who underwent endoscopy without gastric cancer was obtained as control samples. All patients were matched with regard to age and sex. The urease test and histology were used for the diagnosis of H. pylori infection. The prevalence of H. pylori was compared between the two groups. The data analysis was performed using SPSS version 16. through t student, Chi-square test, and Fisher exact tests.
Results: The prevalence of H. pylori infection in gastric adenocarcinoma group was 92% and in the control group was 60%. The prevalence of H. pylori infection in gastric adenocarcinoma patients was 100% in the antropyloric region and 95% in the body of the stomach.
Conclusion: There is a significant correlation between Helicobacter pylori infection and risk of gastric adenocarcinoma.
Ayoub Najaf-Zadeh, Hamid Reza Ghaffari,
Volume 26, Issue 4 (9-2020)
Abstract
Aims: Cancerous brain tumors are among the most dangerous diseases that lower the quality of life of people for many years. Their detection in the early stages paves the way for the proper treatment. The present study aimed to present a two-dimensional Convolutional Neural Network (CNN) for detecting brain tumors under Magnetic Resonance Imaging (MRI) using the deep learning method.
Methods & Materials: The proposed method has two stages of feature extraction and classification. A 12-layer CNN was used to extract the features of the MRI images and then the softmax activation function was used to classify these features. The proposed method was applied to a standard database consisting of three brain tumor types of meningioma, glioma, and pituitary.
Findings: The proposed method had better performance compared to previously presented methods. Its accuracy was reported as 98.68%.
Conclusion: Meningioma, glioma, and pituitary tumors are the most common types of brain tumors. Early detection of these tumors can decrease the risk of death. Because of its fully connected structure, the use of proposed deep CNN can help physicians to correctly detect brain tumors with MRI images.