Dr Raheleh Derafshi, Dr. Alireza Mohammadzadeh, Dr. Saeid Erfanpour, Dr. Elahe Amiri, Dr. Omid Pouresmaeil, Dr. Jalal Mardaneh,
Volume 29, Issue 2 (3-2023)
Background: Urinary tract infection (UTI) is the most common urinary system disease, which is considered a contributing factor to renal failure. The present study aimed to evaluate the significance of hyponatremia in the diagnosis and treatment of hospitalized patients with UTI at Allameh Bohlol Gonabadi Hospital in Gonabad City, Iran.
Materials and Methods: This cross-sectional study was conducted on 384 collected samples from patients diagnosed with UTI from 2013 to 2017. Demographic and clinical data of the patients were recorded using a checklist. The samples were divided into two groups: hyponatremia and non-hyponatremia, and variables including leukocyte count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and duration of fever were examined. After sample collection, the data were analyzed using the SPSS (version 20) software and Chi-squared and Mann-Whitney statistical tests.
Findings: In this study, 384 individuals with febrile UTI were examined, of which 71.6% were female and 28.4% were male. Hyponatremia was present in 57.6% of individuals with UTI. No significant correlation was found between age, gender, and hyponatremia (P=0.189 and P=0.238, respectively). Patients with hyponatremia had increased leukocyte count, elevated ESR, and positive CRP. A significant association was observed between hyponatremia and CRP, ESR, leukocyte count, and duration of fever (P<0.001).
Conclusion: The results demonstrated that hyponatremia may serve as a marker in the diagnosis of febrile renal infections, and its presence at the time of diagnosis suggests a likelihood of pyelonephritis and severe inflammation.
