Internal Medicine Today
طب داخلی روز
Intern Med Today
Medical Sciences
http://imtj.gmu.ac.ir
80
journal80
2981-0086
2981-0086
10.18869/acadpub.hms
en
jalali
1397
6
1
gregorian
2018
9
1
24
4
online
1
fulltext
fa
بررسی تاثیر محرومیت از تیمار مادری بر وابستگی به مورفین و یادگیری و حافظه فضائی موشهای صحرایی
Evaluating Effects of Maternal Separation on Morphine-dependency and Spatial Learning and Memory of Rats
فيزيولوژی پزشکی
Physiology
پژوهشی
Original
<div style="text-align: justify;"><strong><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">اهداف</span></span></span></strong><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">: مواجه شدن با محرومیت از تیمار مادری در ابتدای زندگی منجر به ایجاد اختلال در فعالیت</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">های شناختی و نوروشیمیائی مغز می</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">شود. هدف مطالعه حاضر بررسی تاثیر محرومیت از تیمار مادری بر یادگیری و حافظه فضائی موش</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">های صحرائی وابسته به مورفین بوده</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">است.</span></span></span><br>
<strong><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">مواد و روش</span></span></span></strong><strong><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span></strong><strong><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">ها:</span></span></span></strong><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"> مطالعه تجربی حاضر روی 40 سر موش صحرائی نر نژاد ویستار 45 روزه در گروه</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">های کنترل (</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-size:9.0pt;">CO</span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">)، وابسته به مورفین (</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-size:9.0pt;">MD</span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">) و 3 گروه از موش</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">هایی که طی یک (</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-size:9.0pt;">MS1</span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">)، دو (</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-size:9.0pt;">MS2</span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">) و سه (</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-size:9.0pt;">MS3</span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">) هفته اول پس از تولد روزانه 3 ساعت از تیمار مادری محروم بودند، انجام شد. به</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">جز گروه کنترل بقیه گروه</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">ها هر 12 ساعت یک</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">بار 10 میلی</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">گرم بر کیلوگرم وزن بدن مورفین</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"> سولفات به</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">صورت زیرپوستی به</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">مدت 10 روز دریافت کردند. در روز یازدهم علائم سندروم محرومیت بررسی شد و طی 4 روز بعد یادگیری فضائی در ماز آبی موریس سنجیده شد. روز آخر نیز حافظه فضائی بررسی گردید.</span></span></span><br>
<strong><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">یافته</span></span></span></strong><strong><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span></strong><strong><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">ها: </span></span></span></strong><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">اگرچه وابستگی به مورفین بر یادگیری و حافظه فضائی موش</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">های صحرائی تاثیری نداشت، اما محرومیت از تیمار مادری به مدت 3 هفته باعث شد حیوانات به</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">منظور یافتن سکوی پنهان زمان و مسافت بیشتری را در مقایسه با گروه </span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">CO</span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"> صرف کنند (0.001></span></span></span><em><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">p</span></span></span></em><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"> برای هردو مقایسه). همچنین، باعث شد موش</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">های صحرائی زمان کمتر و مسافت کمتری را در ربع هدف در مرحله بازخوانی حافظه بگذرانند (0.001></span></span></span><em><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">p</span></span></span></em><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"> برای هردو مقایسه).</span></span></span><br>
<strong><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">نتیجه</span></span></span></strong><strong><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span></strong><strong><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">گیری:</span></span></span></strong><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"> درمجموع می</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">توان گفت محرومیت از تیمار مادری باعث ایجاد اختلال در یادگیری و حافظه فضائی موش</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">های صحرائی می</span></span></span><span dir="LTR" style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;"></span></span></span><span style="letter-spacing:-.05pt;"><span style="font-family:irbadr;"><span style="font-size:10.0pt;">شود.</span></span></span></div>
<p class="Basic-Paragraph para-style-override-4" font-size:="" new="" style="color: rgb(0, 0, 0); text-align: justify;" text-align:="" times=""></p>
<p class="Basic-Paragraph para-style-override-4" font-size:="" new="" style="color: rgb(0, 0, 0); text-align: justify;" text-align:="" times=""><span class="times-11-r char-style-override-9">Aims: </span><span class="times-11-r">Facing maternal separation during early postnatal life leads to disturbances in the cognitive and neuro-chemical activities of the brain. The aim of this study was to investigate the effects of maternal separation on spatial learning and memory of morphine-dependent rats.</span></p>
<p class="Basic-Paragraph para-style-override-4" font-size:="" new="" style="color: rgb(0, 0, 0); text-align: justify;" text-align:="" times=""><span class="times-11-r char-style-override-9">Materials and Methods:</span><span class="times-11-r"> This experimental study was carried out on 40 male Wistar rats of 45 days old. Animals were divided into control group (CO), morphine dependent (MD) and 3 group of rats which maternally separated during 1 (MS1), 2 (MS2) and 3 weeks (MS3) after birth. Except CO rats, the other groups were subcutaneously injected 10 mg/kg morphine every 12 hours for 10 days. At the 11th day signs of withdrawal syndrome were evaluated and during next 4 consecutive days spatial learning was evaluated by Morris water maze (MWM). The rats’ spatial memory retrieval was also estimated at the last day.</span></p>
<p class="Basic-Paragraph para-style-override-4" font-size:="" new="" style="color: rgb(0, 0, 0); text-align: justify;" text-align:="" times=""><span class="times-11-r char-style-override-9">Findings:</span><span class="times-11-r"> Although morphine dependence did not affects spatial learning and memory of rats, but 3 weeks maternal separation caused the animals spend more time and travel more distance to find the hidden platform than to CO group (</span><span class="times-11-r char-style-override-10">P</span><span class="times-11-r"><0.001 for both of comparisons). Also, they spent less time and passed less distance in the target quadrant in probe trial (</span><span class="times-11-r char-style-override-10">P</span><span class="times-11-r"><0.001 for both of comparisons).</span></p>
<p class="Basic-Paragraph para-style-override-4" font-size:="" new="" style="color: rgb(0, 0, 0); text-align: justify;" text-align:="" times=""><span class="times-11-r char-style-override-9">Conclusion:</span><span class="times-11-r"> In conclusion, maternal separation impairs spatial learning and memory of rats.</span></p>
محرومیت از تیمار مادری, مورفین, یادگیری ماز, حافظه فضائی, موش صحرائی
Maternal deprivation (https://www.ncbi.nlm.nih.gov/mesh/68008426), Morphine (https://www.ncbi.nlm.nih.gov/mesh/68009020), Maze learning (https://www.ncbi.nlm.nih.gov/mesh/68018782), Spatial memory (https://www.ncbi.nlm.nih.gov/mesh/68065852), Rats (https:
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http://imtj.gmu.ac.ir/browse.php?a_code=A-10-1984-3&slc_lang=fa&sid=1
GH.
Hamidi
غلامعلی
حمیدی
hamidi_gh@kaums.ac.ir
8000319475328460027065
8000319475328460027065
No
Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.
مرکز تحقیقات فیزیولوژی، دانشگاه علوم پزشکی کاشان، کاشان، ایران
M.
Salami
محمود
سلامی
salami-m@kaums.ac.ir
8000319475328460027066
8000319475328460027066
No
Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.
مرکز تحقیقات فیزیولوژی، دانشگاه علوم پزشکی کاشان، کاشان، ایران
A.R.
Talaei
سید علیرضا
طلائی
talaei@kaums.ac.ir
8000319475328460027067
8000319475328460027067
Yes
Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.
مرکز تحقیقات فیزیولوژی، دانشگاه علوم پزشکی کاشان، کاشان، ایران