Aims: Physical exercises have a positive effect in preventing and treatment of obesity and diabetes. Regulation of lipid tissue derived hormones like adiponectin, CRP and IL-6, may have effect in this. The purpose of this study was to determine the effect of combination training on adiponectin, CRP, Insulin Resistance Index and IL-6 in inactive men.

 Methods: In this quasi-experimental study, a sample of 20 inactive men was selected by random sampling method among 100 suitable volunteers in 2011 in Mobarakeh city and was randomly divided in 2 equal experimental and control groups. The used exercise protocol included 36 sessions of combinational exercises (aerobic-resistance) during 12 weeks. The control group didn't perform any physical exercises. At the end of the combinational exercise, blood samples were collected from both groups. Adiponectin, CRP, IL-6 and insulin resistance index were measured before and 12 weeks after exercise training.

Results: At the end of the 12 weeks, improvements in fitness, body composition and insulin sensitivity were observed, but these changes were not associated with decreased CRP or increased adiponectin levels. After 12 weeks of combinational exercise, a significant decrease was seen in insulin concentration and insulin resistance index in exercise group, but there were no significant change in adiponectin, CRP and IL-6 concentration before and after 12 weeks of training.

Conclusion: Aerobic-resistance combination exercise cannot improve the level of adiponectin, CRP and IL-6 and the changes in insulin resistance index cannot explain the changes of inflammatory markers’ level.