Aims: Obesity is one of the most common problems in societies which can induce many diseases. Some methods have been suggested and are used for the treatment of obesity which herbal therapy is one of them. The aim of this study was to determine the effect of Fitana herbal compound as an anti-obesity product on weight and blood lipid profile in male Wistar rats.

Methods: In this study 40 male Wistar rats with the average weight of 280-300g were used. The rats were divided into 5 groups as experimental I (200mg/kg of aqueous extract of Fitana), and experimental II (400mg/kg of aqueous extract of Fitana), experimental III (200mg/kg of alcoholic extract of Fitana), control I (negative control) and control II (5mg/kg of Orlistat). Data were analyzed by SPSS 11.5 using Tukey and ANOVA tests.

Results: There was no significant difference in the mean of weight and BMI among experimental groups. Triglyceride level was only decreased significantly in experimental group II (62.62±9.94 p=0.0014) and III (62.12±12.02 p=0.011) in comparison with negative control group (84.37±13.51mg/dl).

Conclusion: Oral consumption of Fitana herbal compound can reduce triglyceride level in blood.