Volume 20, Issue 1 (4-2014)
Intern Med Today 2014, 20(1): 23-27 |
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Rahimi Asl F, Farbood Y, Sarkaki A, Hosseini S E. The effect of Acid Gallic Impacts on Passive Memory in Mature Female Rats under the Complete Brain Ischemia Conditions. Intern Med Today 2014; 20 (1) :23-27
URL: http://imtj.gmu.ac.ir/article-1-1853-en.html
URL: http://imtj.gmu.ac.ir/article-1-1853-en.html
1- Islamic Azad University Fars Science and Research Bran Science and Research Branch
2- Ahwaz Jundishapur University of Medical Sciences
3- Islamic Azad University Fars Science and Research Bran Science and Research Branch , ebrahim.hossini@yahoo.com
2- Ahwaz Jundishapur University of Medical Sciences
3- Islamic Azad University Fars Science and Research Bran Science and Research Branch , ebrahim.hossini@yahoo.com
Abstract: (5680 Views)
Aims: Cerebral ischemia is a condition that to the all or parts of the brain does not reach blood and as a result enough oxygen. Due to the debilitating effects of cerebral ischemia, this study was done to investigate the effect of Gallic acid on passive avoidance memory in adult female rats under bilateral cerebral ischemia condition.
Methods: 84 rats were randomly divided into 6 control (C without any manipulation of carotid artery and treatment), Gallic acid control (CGA without any manipulation of carotid artery and treated with Gallic acid), ischemia control (CI manipulated with carotid artery but not occlusion and without treatment), ischemia (I complete and bilateral occlusion of carotid arteries and without treatment), solvent ischemia (IS complete and bilateral occlusion of carotid arteries with normal saline gavage) and Gallic acid ischemia (IGA complete and bilateral occlusion of carotid arteries with Gallic acid gavage) groups each had 14 rats. The shuttle box was used to investigate the passive avoidance learning behavior. Data were analyzed using One-way ANOVA and LSD logistic tests.
Results: After the application of electric shocks, the STL time in each of the I and IS groups had significant reduction compared to CI group and in IGA group increased significantly compared to I group. 72 hours after application of electric shock, the STL time in CGA group had a significant increase compared to the CI group and 7 days after the application of electric shock the STL time in IGA group had a significant decrease compared to CI group.
Conclusion: Gallic acid increases the passive avoidance memory in rats with cerebral ischemia.
Type of Study: Original |
Subject:
Basic Medical Science
Received: 2013/10/5 | Accepted: 2014/03/19 | Published: 2014/03/19
Received: 2013/10/5 | Accepted: 2014/03/19 | Published: 2014/03/19
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