Volume 22, Issue 2 (Spring 2016)                   Intern Med Today 2016, 22(2): 111-116 | Back to browse issues page

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Rashidlamir A, Basami M R, Attarzadeh Hosseini S R, Hejazi K, Motevalli Anberani S M. 8 Weeks of Resistance Training Effect on Myostatin Gene Expression of Myocardium in Healthy Male Wistar Rats. Intern Med Today 2016; 22 (2) :111-116
URL: http://imtj.gmu.ac.ir/article-1-2203-en.html
1- Sport Physiology Department, Sport Sciences Faculty, Ferdowsi University of Mashhad, Mashhad, Iran , rashidlamir@um.ac.ir
2- Clinical Sciences Department, Veterinary Medicine School, Ferdowsi University of Mashhad, Mashhad, Iran
3- Sport Physiology Department, Sport Sciences Faculty, Ferdowsi University of Mashhad, Mashhad, Iran
Abstract:   (6342 Views)

Aims: Based on the clinical studies, there are higher myostatin gene expression and serum level in cardiovascular patients than the healthy persons. In addition, based on some studies, regular resistance exercises is in line with a reduction in the myostatin gene expression. The aim of this study was to investigate the effects of 8-week resistance exercises on the myostatin gene expressions of myocardium in the healthy male Wistar rats. 

Materials & Methods: In the experimental study, 13 male adult Wistar rats, aged 15 weeks, were divided into experimental (n=7) and control (n=6) groups. In experimental group, 8-week exercises were done as climbing up a 26-step 1-meter ladder, inclined 85°, with a sinker. (There were 3 sessions a week exercises; each session consisted of 3 sets of 5 repetitions.) 24 hours after the last exercise session and after 12-hour fasting, the rats being dissected, muscle tissue samples were prepared to assess mRNA levels. Data was analyzed in SPSS 16 software using independent T test.

Findings: After 8-week resistance exercises, there was no significant difference in the myostatin mRNA expression level in the myocardium between experimental (1.56±0.44) and control (1.94±0.55) groups (p=0.197).

Conclusion: 8-week resistance exercises leads to no significant change in the myostatin gene expression of myocardium in the healthy Wistar male rats.

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Type of Study: Original | Subject: Physiology
Received: 2015/05/6 | Accepted: 2015/11/14 | Published: 2016/02/17

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