Volume 23, Issue 1 (Winter 2017)                   Intern Med Today 2017, 23(1): 63-67 | Back to browse issues page

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Moeini Moghaddam R, Shalizar Jalali A, Najafi G, Behfar M. Effect of Sildenafil in Protection of Contralateral Testis Following Unilateral Blunt Testicular Trauma in Mouse. Intern Med Today 2017; 23 (1) :63-67
URL: http://imtj.gmu.ac.ir/article-1-2354-en.html
1- Basic Sciences Department, Veterinary Medicine Faculty, Urmia University, Urmia, Iran
2- Basic Sciences Department, Veterinary Medicine Faculty, Urmia University, Urmia, , a.shalizar@urmia.ac.ir
3- Surgery & Diagnostic Imaging Department, Veterinary Medicine Faculty, Urmia University, Urmia, Iran
Abstract:   (5233 Views)

Aims: Caused mainly by the contact sports, the non-penetrating testicular trauma in some children might produce post-maturity fertility problems in men. The aim of the study was to investigate the adjacent-testis protective role of sildenafil after the non-penetrating one-way testicular trauma in the rats.

Materials & Methods: In the experimental study, 24 non-mature male rats (20 days old) were studied. The rats were randomly divided into four 6-rat groups including control, non-penetrating trauma, non-penetrating trauma + sildenafil, and sildenafil groups. To produce the non-penetrating trauma, the belly being opened, the right testis, put on a sterile constant level, was hit by a sterile 5g weight released from 10cm height. 0.1mg/kg sildenafil were administrated as intra-peritoneal injection daily and for 7 days after the trauma. The left testis of all the rats, removed in their 70 days old, were histologically investigated. Data was analyzed using one-way ANOVA and Tukey’s post-hoc tests. 

Findings: The trauma significantly reduced the mean diameter of the seminiferous tubules, their germinal epithelium height, and the spermatogenesis indices. In addition, such trauma caused different morphological changes in the adjacent testis of the rats. All the parameters were considerably improved by the administration of sildenafil (p<0.05). 

Conclusion: The sildenafil can protect the rats against the fertility disorders caused by the non-penetrating one-way testis trauma. 

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Type of Study: Original | Subject: Basic Medical Science
Received: 2015/11/15 | Accepted: 2016/07/19 | Published: 2016/12/31

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