Introduction: As a traditional treatment in many countries, the seeds of Nigella sativa are used to prevent and heal many diseases like diabetes, asthma, cough, nasal congestion, headache, toothache, intestinal worms, menstrual disorders, gastrointestinal diseases, and sexual dysfunction. The aim of this study was to review the published scientific reports about the physiologic effects of the seeds of Nigella sativa on different organs of body. In the review, scientific papers on the effects of the seeds of Nigella sativa on the functions of different organs of body, published between 1980 and 2015, were investigated and collected using Medline and SID databases.

Conclusion: Based on the laboratory studies, the seeds of Nigella sativa are with liver, kidney, gastrointestinal, nervous system, and cardiovascular protective effects, as well as anti-inflammatory, anti-cancer, anti-bacterial, and anti-parasite effects. Nigella sativa reduces blood pressure, blood sugar, and hyperlipidemia. Nevertheless, there are no expanded studies on the herb. No doubt, based on the results of laboratory studies and documents about its consumption administrated in the traditional medicine, it is useful to consume the herb in cases including a mild high blood pressure, as well as blood sugar increase and hyperlipidemia. However, it requires more human studies.