Aims: Multiple sclerosis (MS) is a result of the destruction of myelin cells in the central nervous system, which can damage the motor system, increase fatigue and decrease the daily activity of life. The aim of the study was to investigate the effect of 10 weeks of aerobic exercise in water on the levels of chemerin, insulin and serum insulin resistance in women with (MS).

Materials & Methods: In the semi-experimental study with pre-test and post-test design with control group in 2015, 29 MS female patients were selected through available and targeted sampling method and were divided into two experimental groups (n = 15) and control (n = 14). The aerobic exercise program included 10 weeks of aerobic exercise in water, each week 3 sessions, and each session for 45 to 60 minutes with an intensity equal to 60 to 75% of the maximum heart rate. Chromic and serum insulin values were measured before and after the end of the aerobic exercise period. Data were analyzed by SPSS 20 software using two-way ANOVA and paired T tests.

Findings: 10-week aerobic exercise program in water resulted in a significant decrease in average of chemerin levels (p=0.01), fasting glucose (p=0.03), insulin (p=0.04) and insulin resistance (p=0.01) in women with (MS), but there was no significant difference in mean body mass and body mass index (p<0.05).

Conclusion: 10 weeks of aerobic exercise in water leads to lower levels of chemerin, insulin and serum insulin resistance in women with MS.