Volume 23, Issue 4 (Autumn 2017)
Intern Med Today 2017, 23(4): 331-338 |
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TaheriChadorneshin H, Ranjbar K, Nourshahi M. A Review of Response of Angiogenic and Angiostatic Factors to Exercise. Intern Med Today 2017; 23 (4) :331-338
URL: http://imtj.gmu.ac.ir/article-1-2588-en.html
URL: http://imtj.gmu.ac.ir/article-1-2588-en.html
1- Sport Sciences Department, Human Sciences Faculty, University of Bojnord, Bojnord, Iran , kh.taheri_62@yahoo.com
2- Physical Education & Sport Science Department, Human Sciences Faculty, Bandar Abbas Branch, Islamic Azad University, Bandar Abbas, Iran
3- Exercise Physiology Department, Sport Sciences Faculty, Shahid Beheshti University, Tehran, Iran
2- Physical Education & Sport Science Department, Human Sciences Faculty, Bandar Abbas Branch, Islamic Azad University, Bandar Abbas, Iran
3- Exercise Physiology Department, Sport Sciences Faculty, Shahid Beheshti University, Tehran, Iran
Abstract: (4891 Views)
Aims: Angiogenesis and angiostasis processes mean the forming and preventing the formation of a new capillary from pre-capillary, respectively. Angiogenesis due to exercise is controlled by the balance between angiogenic and angiostatic factors. Angiogenesis due to exercise training by increasing capillary density in muscle fibers improves the transfer of oxygen and nutrients to the muscle. The aim of this review was to evaluate the response of each of these angiogenic and angiostatic factors to exercise.
Conclusion: Vascular endothelial growth factor, transforming growth factor-β, angiopoiten and matrix metalloproteinase are most important angiogenic factors that show an up-regulated response following exercise. In contrast, angiostatin, endostatin, thrombospondine 1, and tissue inhibitor of metalloproteinase act as most important angiostatic factors. Although their functions in cell culture are cleared, further research is still necessary to obtain more consistent conclusions about response of inhibiting factors in both of physiologic and pathologic conditions following exercise.
Conclusion: Vascular endothelial growth factor, transforming growth factor-β, angiopoiten and matrix metalloproteinase are most important angiogenic factors that show an up-regulated response following exercise. In contrast, angiostatin, endostatin, thrombospondine 1, and tissue inhibitor of metalloproteinase act as most important angiostatic factors. Although their functions in cell culture are cleared, further research is still necessary to obtain more consistent conclusions about response of inhibiting factors in both of physiologic and pathologic conditions following exercise.
Keywords: Angiogenic Proteins: [http://www.ncbi.nlm.nih.gov/mesh/68042501], Angiogenesis Inhibitors: [http://www.ncbi.nlm.nih.gov/mesh/68020533], Exercise: [http://www.ncbi.nlm.nih.gov/mesh/68015444]
Type of Study: Review |
Subject:
Basic Medical Science
Received: 2016/09/2 | Accepted: 2017/05/21 | Published: 2017/09/19
Received: 2016/09/2 | Accepted: 2017/05/21 | Published: 2017/09/19
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