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Background and Aim: Eye color is of a genetic origin and is basically characterized by the accumulation and distribution of melanin and lipochrome pigments in the iris. Pigments in the iris cause its blue color turning to green, hazel and brown with the increase in the iris pigmentation. Although normally Cup/Disc (C/D) ratio can range from 0 to 0.8, normally the ratio is less than 0.3. This study is mainly intended to examine the relationship of iris and pupil margin pigmentation with optic Disc CUP in subjects with no primary or secondary ocular disease. Materials and Methods The target population of this descriptive analytical study included women referring to Sabzevar Eye Clinic. They were examined by slit lamp for the color of their iris in three groups: dark brown, medium brown (green) and light brown (blue). Their pupil margin pigmentations were qualitatively divided into five groups: those with one, two, three or many rows of pigmentation and those with no pigmentation. C/D ratio was qualitatively estimated upon funduscopy by direct ophthalmoscope. The obtained data were statistically analyzed using Chi-Square and Fisher's exact test. Results: Total sample was 227 mean OD and OS CUP were 0.1617 ±0.1178 and 0.1648 ±0.1197 respectively. CUP ranged from 0 to 0.5 but the most frequent OD and OS CUP were 0.2 and 0.1 respectively the least frequent in both eyes was 0.5. The most common iris color was dark brown (55.9%) the most common pigmentation of the pupil margin was 47% in two rows. 4.5% of the subjects were observed to be asymmetric as for the CUP of their eyes it was 0.9% for CUP of 0, 0.1 and 0.2 it was 0.5% for CUP of 0.3 also 1.3% for CUP of 0.4 no asymmetry was observed for CUP of 0.5. No significant relationship was observed to exist between OD and OS CUP with iris color and pupil margin pigmentation. But OD CUP 0 indicated a correlation at P=0.041 while no such relationship was found in the left eye. Significant relationships were also observed for OD CUP of 0.1, 0.4 and 0.5 with eye color at p-values of 0.004 for blue, 0.038 and 0.035 for medium brown (green). Relationships of CUP and OD pupil margin pigmentation were also obtained for CUP of 0.1 and three rows (P=0.048), CUP of 0.2 and two rows (P=0.020) and no pigmentation (P=0.036). In the left eye, relationships were obtained for CUP of 0.1 and pupil margin pigmentation for two rows (P=0.024), and three rows (P=0.03) for CUP of 0.2 and two rows (P=0.018), three rows (P=0.024) and with no pigmentation (P=0.031). Conclusion: As no significant relationships were observed in the relationships of CUP, eye color and pupil margin pigmentation, except for some particular CUP, iris color and pupil margin pigmentation which indicated significant relationships, the issue demands more research to help make scientific predictions of these relations on the basis of certain landmarks.

Keywords: Iris; Color; Pigmentation; Pupil; CUP

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