Volume 26, Issue 4 (Autumn 2020)                   Intern Med Today 2020, 26(4): 332-347 | Back to browse issues page

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Zohrabi Karani L, Farzanegi P, Azarbayjani M A. The Effect of 8-Weeks of Low-Intensity Swimming Training on Promyelocytic Leukemia Zinc Finger Protein and Spermatid Transition Nuclear Protein Gene Expression in Azoospermic Rats Model. Intern Med Today 2020; 26 (4) :332-347
URL: http://imtj.gmu.ac.ir/article-1-3423-en.html
1- Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran.
2- Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran. , parvin.farzanegi@gmail.com
3- Department of Exercise Physiology, Tehran Central Branch, Islamic Azad University, Tehran, Iran.
Abstract:   (2392 Views)
Aims: One of the causes of infertility in men is the azoospermia disease, which is attributed to the lack of sperm in each sperm. The primary function of spermatogenesis is the maintenance, proliferation, and differentiation of spermatogonial cells. Thus, the present study aimed to investigate the changes in Promyelocytic Leukemia Zinc Finger (PLZF) and spermatid Transition Nuclear Protein (TNP) gene expression levels in an azoospermic rat model after 8 weeks of low-intensity aerobic training.
Methods & Materials: In this experimental study, 15 adult male Wistar rats were randomly divided into three groups of healthy control, with azoospermia, and exercise plus azoospermia after creating an azoospermia model. The patient plus exercise group performed a low-intensity swimming exercise 30 minutes a day, five days a week for 8 weeks, after the creation of the azoospermic rats. A One-way ANOVA test was used for data analysis.
Findings: The results showed that a period of swimming exercise program in the exercise plus azoospermia
group significantly reduced PLZF gene expression compared to the healthy control groups (P=0.001) and no significant increase to the azoospermia group (P=0.06). There was also a significant decrease in TNP gene expression levels in the exercise plus azoospermia group compared to the healthy control group (P=0.001) and a significant increase in the azoospermia group (P=0.057).
Conclusion: Based on these Findings, it can be stated that the alteration of key molecules or signaling pathways and expression of the PLZF and TNP genes in the spermatogenesis process may increase infertility, but regular aerobic exercise, such as low-intensity swimming, helps to control the effects of infertility by increasing the maintenance and development of spermatogonial stem cells.
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Type of Study: Original | Subject: Physiology
Received: 2019/11/16 | Accepted: 2020/01/6 | Published: 2020/10/1

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