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Volume 27, Issue 4 (Autumn 2021)                   Intern Med Today 2021, 27(4): 450-465 | Back to browse issues page


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Ghaderi Goodarzi S, Abbassi Daloii A, Abdi A, Saeidi A. The Effect of 12 Weeks Combined Training and Caffeine on Plasma Levels of Interleukin-1β and Interleukin 10 in Obese Men. Intern Med Today 2021; 27 (4) :450-465
URL: http://imtj.gmu.ac.ir/article-1-3629-en.html
1- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
2- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran. , abbasi.daloii@gmail.com
3- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Damghan Branch, Islamic Azad University, Damghan, Iran.
Abstract:   (1465 Views)
Aims: Physical inactivity is associated with low-grade systemic inflammation and increased risk of chronic diseases. Beneficial effects of caffeine on adipocytes metabolism and its anti-inflammatory properties have been reported. This study aimed to evaluate the impact of 12 weeks of combined training and caffeine on plasma levels of inflammatory and anti-inflammatory indices in obese men. 
Methods & Materials: In a quasi-experimental trial, 44 obese men were purposefully and accessibly selected and assigned into four groups each 11 samples: 1) control, 2) combined (resistance-endurance) training, 3) caffeine, and 4) combined training with caffeine. The study subjects received 6 mg of caffeine per kilogram of body weight daily for 12 weeks. The combined training program was performed for 12 weeks, 3 sessions per week. The plasma levels of inflammatory (interleukin[IL]-1β) and anti-inflammatory (IL-10) indices were measured using an ELISA kit. The obtained data were analyzed by dependent t test, 1-way ANOVA, and Tukey post hoc test at the significant level of P<0.05.
Findings: The results showed that 12 weeks of combined training, caffeine, and combined training-caffeine significantly reduced IL-1β levels and increased IL-10 in obese men at posttest compared to the pretest (P=0.001). Also, changes in IL-1β and IL-10 levels were greater in the combined training-caffeine group (P=0.001). 
Conclusion: Combined training with caffeine positively affects body composition and improves inflammatory and anti-inflammatory indices in obese people. 
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Type of Study: Original | Subject: Physiology
Received: 2020/12/11 | Accepted: 2021/01/27 | Published: 2021/10/1

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