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Volume 28, Issue 4 (Autumn 2022)                   Intern Med Today 2022, 28(4): 448-463 | Back to browse issues page


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Kazemi A, Kerendi H, Naghizadeh S. Investigating the Effects of Four Weeks of Spinal Nerve Ligation After a Period of Combined Training on the Expression of Involved Genes in Calcium Current in Plantaris Muscle of Male Wistar Rats. Intern Med Today 2022; 28 (4) :448-463
URL: http://imtj.gmu.ac.ir/article-1-3893-en.html
1- Department of Sports Sciences, Faculty of Literature and Humanities, Vali-e-Asr University, Rafsanjan, Iran. , a.kazemi@vru.ac.ir
2- Department of Physical Education and Sports Sciences, Faculty of Literature and Humanities, Lorestan University, Khorramabad, Iran.
3- Department of Sports Sciences, Faculty of Literature and Humanities, Kerman Branch, Islamic Azad University, Kerman, Iran.
Abstract:   (388 Views)
Aims This study aims to investigate the effect of spinal nerve ligation (SNL) after a period of combined training on the expression of some genes that are involved in the calcium flow in the plantaris muscle of male Wistar rats. 
Methods & Materials A total of 16 adult male Wistar rats were randomly divided into 2 groups, namely the control-SNL (n=8) and combined training-SNL (n=8). The animals in the training group participated in a training program for 6 weeks. After this period, the protocol of spinal SNL was performed on the research groups for 4 weeks. Finally, the rats were dissected and the plantaris muscle was removed. Real-time polymerase chain reaction was used to measure the mRNA expression of STIM1, ORAI1, and MG29 genes. 
Findings In the combined training-SNL group, an increase in the expression of STIM1 (P=0.01), ORAI1 (P=0.002), and MG29 (P=0.02) was observed when compared to the control-SNL group. 
Conclusion The results of the present study showed that SNL reduces the expression of STIM1, ORAI1, and MG29 in the plantaris muscle. Meanwhile, combined training before SNL has a compensatory effect in this regard. 
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Type of Study: Original | Subject: Physiology
Received: 2022/05/13 | Accepted: 2022/09/23 | Published: 2022/09/23

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