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Intern Med Today 2023, 30(1): 0-0 |
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Mohammadzadeh H, Ghorabi A, Majidi M. Clear Cell Hidradenoma of the Right Lower Eyelid without Recurrence:
A Case Report. Intern Med Today 2023; 30 (1)
URL: http://imtj.gmu.ac.ir/article-1-4075-en.html
URL: http://imtj.gmu.ac.ir/article-1-4075-en.html
1- Assistant Professor, Gonabad University of Medical Sciences, Gonabad, Iran , Mohammadzadeh.hamideh@yahoo.com
2- Student Research Committee, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
3- Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran
2- Student Research Committee, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
3- Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran
Abstract: (16 Views)
Aims Clear cell hidradenoma (CCH) is a rare benign tumor that originates in the eccrine glands and tends to occur in the upper extremities and face. In the differential diagnosis of benign tumors of the head and neck, malignant hidradenocarcinoma presents with a similar appearance. Still, it has a more aggressive clinical course and high rates of local nodal metastasis.
Case Presentation A 70-year-old female patient presented with a 1.5×1.5×1 cm, non-tender, reddish-purple, lobular nodule on the right lower eyelid. A small, asymptomatic nodular lesion persisted for 6 years and began to grow over the last 2 years. It is worth mentioning that the lesion was odorless at the time. The lesion had a malodor and purulent infiltration. Due to the patient’s age and gender, a differential diagnosis of Basal Cell Carcinoma was made, and an excisional biopsy was performed to rule out these possibilities. A 0.6×0.6×0.5 skin punch biopsy revealed skin tissue showing nests of cells with clear and eosinophilic cytoplasm within the dermis, consistent with features of CCH. Marked vascularity and small lumina were present, and based on these histopathological findings, a diagnosis of CCH was made. H&E staining was performed, confirming our previous diagnosis of CCH. Under local anesthesia, a nodule measuring 1.5×2×1 was surgically excised. There was no relapse 7 months following excisional surgery, and there were no scars.
Conclusion CCH is a rare benign tumor that typically occurs in the upper extremities and face, but it can also develop in other parts of the body, such as the foot and breast, and can be challenging to diagnose. The diagnosis is mainly based on biopsy and histological studies. Since it is a benign tumor, it is essential to consider it as a differential diagnosis to prevent misdiagnosis and overtreatment.
Case Presentation A 70-year-old female patient presented with a 1.5×1.5×1 cm, non-tender, reddish-purple, lobular nodule on the right lower eyelid. A small, asymptomatic nodular lesion persisted for 6 years and began to grow over the last 2 years. It is worth mentioning that the lesion was odorless at the time. The lesion had a malodor and purulent infiltration. Due to the patient’s age and gender, a differential diagnosis of Basal Cell Carcinoma was made, and an excisional biopsy was performed to rule out these possibilities. A 0.6×0.6×0.5 skin punch biopsy revealed skin tissue showing nests of cells with clear and eosinophilic cytoplasm within the dermis, consistent with features of CCH. Marked vascularity and small lumina were present, and based on these histopathological findings, a diagnosis of CCH was made. H&E staining was performed, confirming our previous diagnosis of CCH. Under local anesthesia, a nodule measuring 1.5×2×1 was surgically excised. There was no relapse 7 months following excisional surgery, and there were no scars.
Conclusion CCH is a rare benign tumor that typically occurs in the upper extremities and face, but it can also develop in other parts of the body, such as the foot and breast, and can be challenging to diagnose. The diagnosis is mainly based on biopsy and histological studies. Since it is a benign tumor, it is essential to consider it as a differential diagnosis to prevent misdiagnosis and overtreatment.
Type of Study: Case report |
Subject:
Diseases
Received: 2025/02/14 | Accepted: 2025/09/22 | Published: 2023/12/7
Received: 2025/02/14 | Accepted: 2025/09/22 | Published: 2023/12/7
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