Volume 30, Issue 3 (Summer 2024)
Intern Med Today 2024, 30(3): 106-117 |
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Nazeri S, mohammad zadeh F, nattagh E, Askari F. Investigating the Therapeutic Effects of Echium Amoenum Extract on Anxiety, Perceived Stress, and Menstrual Cycle Regulation in Women with Delayed Menstruation: A Triple-Blind Randomized Clinical Trial Protocol. Intern Med Today 2024; 30 (3) :106-117
URL: http://imtj.gmu.ac.ir/article-1-4094-en.html
URL: http://imtj.gmu.ac.ir/article-1-4094-en.html
1- Department of Midwifery, School of Medicine, Gonabad University of Medical Sciences, Gonabad, IR, Iran
2- Department of Epidemiology and Biostatistics, School of Health, Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, IR, Iran
3- Assistant Professor of Nutritional Sciences, Department of Nutrition, Food Sciences and Clinical Biochemistry, School of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, IR, Iran
4- Assistant Professor in Reproductive Health, School of Medicine, Reproductive Health and Population Research Center, Gonabad University of Medical Sciences, Gonabad, IR, Iran ,faribaaskari100@gmail.com
2- Department of Epidemiology and Biostatistics, School of Health, Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, IR, Iran
3- Assistant Professor of Nutritional Sciences, Department of Nutrition, Food Sciences and Clinical Biochemistry, School of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, IR, Iran
4- Assistant Professor in Reproductive Health, School of Medicine, Reproductive Health and Population Research Center, Gonabad University of Medical Sciences, Gonabad, IR, Iran ,
Abstract: (41 Views)
Aims Except in pregnancy, functional hypothalamic amenorrhea (FHA) and polycystic ovary syndrome (PCOS) are the most prevalent causes of secondary amenorrhea. Echium amoenum (EA) Fisch & C.A.Mey. (Iranian Gol-e-Gavzaban or Iranian borage) possesses several notable properties, including anti-stress and anxiolytic effects, the capacity to elevate sex hormones, and the presence of prostaglandin precursor fatty acids. As a result, EA is being considered as a potential treatment for FHA induced by mental stress and PCOS, which may lead to the resumption of ovarian activity. This study aimed to determine the effect of thequeous extract of EA on the level of anxiety, perceived stress, and occurrence of menstruation in women with menstrual postponement referring to public comprehensive health centers and private gynecology clinics in Gonabad, Iran.
Materials & Methods This triple-blind randomized clinical trial was conducted on 82 non-pregnant women with menstruation postponement due to hypothalamic functional stress amenorrhea and polycystic ovarian syndrome. The women were referred to public comprehensive health centers and private gynecology clinics in Gonabad, Iran, in 2023. The subjects were randomly assigned to two groups: the test group (EA aqueous extract) and the control group (placebo) using the convenience sampling method and permutation blocks of size 2 and 4. The test group received 500 mg oral capsules containing the aqueous extract of EA, while the control group received capsules containing cornstarch as a placebo for 6 weeks, taking one capsule every day, 30 minutes after breakfast. Data were collected using demographic and obstetric questionnaires, the Cohen Perceived Stress Scale, the Hamilton Anxiety Rating Scale, a drug consumption form, a menstrual cycle registration questionnaire, and a food plan registration questionnaire. The data were analyzed using SPSS (version 21). The generalized estimating equations model was applied at a significance level of 0.05.
Conclusion If the findings indicate a favorable impact of utilizing EA aqueous extract for managing stress-induced FHA and PCOS, the administration of this herbal remedy may be recommended as a safe intervention with no adverse effects for these patient cohorts.
Materials & Methods This triple-blind randomized clinical trial was conducted on 82 non-pregnant women with menstruation postponement due to hypothalamic functional stress amenorrhea and polycystic ovarian syndrome. The women were referred to public comprehensive health centers and private gynecology clinics in Gonabad, Iran, in 2023. The subjects were randomly assigned to two groups: the test group (EA aqueous extract) and the control group (placebo) using the convenience sampling method and permutation blocks of size 2 and 4. The test group received 500 mg oral capsules containing the aqueous extract of EA, while the control group received capsules containing cornstarch as a placebo for 6 weeks, taking one capsule every day, 30 minutes after breakfast. Data were collected using demographic and obstetric questionnaires, the Cohen Perceived Stress Scale, the Hamilton Anxiety Rating Scale, a drug consumption form, a menstrual cycle registration questionnaire, and a food plan registration questionnaire. The data were analyzed using SPSS (version 21). The generalized estimating equations model was applied at a significance level of 0.05.
Conclusion If the findings indicate a favorable impact of utilizing EA aqueous extract for managing stress-induced FHA and PCOS, the administration of this herbal remedy may be recommended as a safe intervention with no adverse effects for these patient cohorts.
Keywords: Anxiety, Echium amoenum, Medicinal plants, Perceived stress, Randomized controlled trial, Secondary amenorrhea
Type of Study: Original |
Subject:
Obstetrics and Gynecology
Received: 2024/01/12 | Accepted: 2024/02/15 | Published: 2024/05/30
Received: 2024/01/12 | Accepted: 2024/02/15 | Published: 2024/05/30
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