دوره 30، شماره 3 - ( 3-1403 )
جلد 30 شماره 3 صفحات 93-92 |
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Mohebbati R. Policy Brief: Potential of ZiziphusJujuba in the Management of Hypertension. Intern Med Today 2024; 30 (3) :92-93
URL: http://imtj.gmu.ac.ir/article-1-4117-fa.html
URL: http://imtj.gmu.ac.ir/article-1-4117-fa.html
محبتی رضا. خلاصه سیاستی: پتانسیل گیاه عناب بر در مدیریت فشارخون بالا. طب داخلی روز. 1403; 30 (3) :92-93
مرکز تحقیقات پرستاری، دانشگاه علوم پزشکی گناباد، گناباد، ایران ، Mohebbatir@gmail.com
چکیده: (54 مشاهده)
Introduction
Hypertension remains a leading global cause of cardiovascular morbidity and mortality. Despite the availability of various synthetic antihypertensive agents, adverse effects and treatment resistance highlight the need for complementary natural remedies. Ziziphus jujuba (jujube), a member of the Rhamnaceae family, is traditionally used in Iranian medicine for cardiovascular health and may offer therapeutic benefits in blood pressure regulation
Problem
Endothelial dysfunction and nitric oxide (NO) deficiency are central to hypertension pathophysiology. The two major classes of blood pressure control drugs, which act as synthetic NO donors or renin-angiotensin system inhibitors, are often associated with side effects. Therefore, identifying safe Phyto therapeutic options that restore vascular homeostasis via the NO pathway or modulation of the renin-angiotensin system (RAS) is a public health priority in integrative cardiovascular management
Analysis
Animal studies led by Dr. Reza Mohebbati and colleagues have systematically demonstrated the antihypertensive potential of Ziziphus jujuba:
Recommendations
1. Clinical application: Conduct well-designed clinical trials to evaluate standardized jujube extracts in patients with uncontrolled or primary hypertension. It should be noted that clinical work in this area is being carried out by the research team of this project and so far, we have achieved good results.
2. Standardization: Establish phytochemical quality control focusing on active compounds such as jujubesides, saponins and flavonoids. This work was also carried out by the aforementioned team and the presence of effective compounds has been confirmed.
3. Integrated guidelines: It is recommended that jujube supplementation be included in national integrated medicine policies for the prevention of hypertension in high-risk populations.
4. Dose optimization: Encourage further studies on dose-response and toxicity to define safe treatment intervals and avoid contradictory effects at high doses.
5. Mechanistic research: Prioritize molecular research on NO-cGMP signaling and RAS modulation to confirm pharmacodynamic pathways.
Conclusion
The findings from multiple preclinical studies by Dr. Reza Mohabbati's team provide compelling evidence that jujube extract provides vascular protection, primarily through increased endothelial NO signaling and partial suppression of the renin-angiotensin axis. Clinical evidence in an ongoing project has also confirmed these findings so far. Incorporating jujube into evidence-based herbal therapeutic strategies could contribute to safer and more sustainable hypertension management options.
Hypertension remains a leading global cause of cardiovascular morbidity and mortality. Despite the availability of various synthetic antihypertensive agents, adverse effects and treatment resistance highlight the need for complementary natural remedies. Ziziphus jujuba (jujube), a member of the Rhamnaceae family, is traditionally used in Iranian medicine for cardiovascular health and may offer therapeutic benefits in blood pressure regulation
Problem
Endothelial dysfunction and nitric oxide (NO) deficiency are central to hypertension pathophysiology. The two major classes of blood pressure control drugs, which act as synthetic NO donors or renin-angiotensin system inhibitors, are often associated with side effects. Therefore, identifying safe Phyto therapeutic options that restore vascular homeostasis via the NO pathway or modulation of the renin-angiotensin system (RAS) is a public health priority in integrative cardiovascular management
Analysis
Animal studies led by Dr. Reza Mohebbati and colleagues have systematically demonstrated the antihypertensive potential of Ziziphus jujuba:
- L-NAME-induced hypertension model: Long-term administration of hydroalcoholic extract of Ziziphus jujuba (100–400 mg/kg) significantly attenuated the elevation in systolic and mean arterial blood pressure induced by NO inhibition. The lowest dose (100 mg/kg) was most effective, suggesting optimal biological activity at moderate concentrations.
- Angiotensin II-induced hypertension model: Pretreatment with Ziziphus jujuba extract (100–200 mg/kg) decreased blood pressure elevations caused by Ang II administration, indicating partial suppression of the RAS pathway. The effect reversed at higher doses, showing possible biphasic dose-dependency.
- Normotensive response: Hydroalcoholic extract reduced baseline SBP and MAP in normotensive rats only at higher dosages (200–400 mg/kg), implying safety at therapeutic ranges and absence of excessive hypotension
Recommendations
1. Clinical application: Conduct well-designed clinical trials to evaluate standardized jujube extracts in patients with uncontrolled or primary hypertension. It should be noted that clinical work in this area is being carried out by the research team of this project and so far, we have achieved good results.
2. Standardization: Establish phytochemical quality control focusing on active compounds such as jujubesides, saponins and flavonoids. This work was also carried out by the aforementioned team and the presence of effective compounds has been confirmed.
3. Integrated guidelines: It is recommended that jujube supplementation be included in national integrated medicine policies for the prevention of hypertension in high-risk populations.
4. Dose optimization: Encourage further studies on dose-response and toxicity to define safe treatment intervals and avoid contradictory effects at high doses.
5. Mechanistic research: Prioritize molecular research on NO-cGMP signaling and RAS modulation to confirm pharmacodynamic pathways.
Conclusion
The findings from multiple preclinical studies by Dr. Reza Mohabbati's team provide compelling evidence that jujube extract provides vascular protection, primarily through increased endothelial NO signaling and partial suppression of the renin-angiotensin axis. Clinical evidence in an ongoing project has also confirmed these findings so far. Incorporating jujube into evidence-based herbal therapeutic strategies could contribute to safer and more sustainable hypertension management options.
نوع مطالعه: گزارش کوتاه |
موضوع مقاله:
فيزيولوژی پزشکی
دریافت: 1402/5/2 | پذیرش: 1402/11/15 | انتشار: 1403/3/10
دریافت: 1402/5/2 | پذیرش: 1402/11/15 | انتشار: 1403/3/10
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