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Background & Aim: Breast cancer is one of the female’s general cancers and one reason of mortality among them. Regarding the Cyclooxygenase role (COX) and the production of prostaglandinE2 in causing tumor damages in mammary glands, it can be effective to apply components as COX inhibitor to prevent gland cancer. Thus, the present study was carried out to evaluate flunixin as unselected Cyclooxygenase inhibitor enzymes to reveal mammary gland cancer in female Wistar rat. Materials & Methods: The research was conducted to evaluate the role of flunixin as selective preventative of cyclooxygenase in the emergence of breast glands cancer in mice (Wistar race). The experiment groups included a negative control group (for which salin was injected on the breast glands with sesame oil) and a positive control group (to which we injected different values of flunixin). The sample included six rats. In order to inoculate the cancer, we used a compound called DMBA. This compound was injected into the breast glands directly. Then, the entire animal breast was studied in respect to the appearance of cancer damages (weight and diameter) in breast glands and the appearance of clinical symptoms. At the end of the research, we analyzed autopsy findings and microscopy sections of tumor damages in the samples of all groups. Results: In this study, tumor’s weight and thickness decreased in medicine receiving groups, (p≤0.05), and microscopic slice of mammary tissue confirmed the microscopic findings. Conclusion: This study confirms the positive effect of the drug in treating and preventing the mammary cancer in such a way that the microscopically slices provided from breast tissues in the experimental groups (drug receiving groups) indicate that cell cancers are decreasing so that the cells tend to gain their own normal order again.

Keywords: Cyclooxygenase, breast cancer, flunixin, rat

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