Volume 16, Issue 3 (Autumn 2010)                   Intern Med Today 2010, 16(3): 25-32 | Back to browse issues page

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Eslami R, Parnow A H, Gharakhanlou R. The Effect of Strength Training on Calcitonin Gene-related Peptide Content in Slow and Fast Muscles of Wistar Rats. Intern Med Today 2010; 16 (3) :25-32
URL: http://imtj.gmu.ac.ir/article-1-961-en.html
1- , r_eslami1000@yahoo.com
Abstract:   (12453 Views)
Background and Aim: Calcitonin Gene-related Peptide (CGRP), a 37-amino acid peptide, generated by alternative processing of primary transcripts from calcitonin gene, is broadly distributed in the peripheral and central nervous systems of vertebrate and invertebrate species. In addition, CGRP that is transported in somatofugal direction in peripheral nerve probably has a role in the muscle protein synthesis. The purpose of the present study was to investigate the effect of strength training on the content of CGRP in slow (soleus) and fast (tibialis anterior) muscles of wistar rats. Materials and Methods: A number of 12 male Wistar rats (10 months of age, 220±15 gr) were randomly divided into tow groups: control group (n=7) and strength training (n=5). The strength training protocol consisted of climbing a 1-meter-long ladder set at an 85° angle, with a weight attached to the tail. Results: The results showed that there was not a significant difference between slow and fast muscle CGRP of control group. Nonetheless, the strength training led to an increase in CGRP content of slow muscle and a decrease in CGRP content of fast muscle both of which were not significant compared with the control group (p=0.155 and p=0.083), respectively. Conclusion: The findings of the current study show that slow and fast muscle CGRP content changes with strength training and indicate that strength training can remodel NMJ.
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Type of Study: Original | Subject: Basic Medical Science
Received: 2010/12/11 | Accepted: 2021/12/27 | Published: 2010/12/15

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