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Background and Aim: However Hand washing is one of the most important factors in prevention of nosocomial infections, researches finding show that hand washing compliance in health care workers was not satisfying. The concept of compliance is effective hand hygiene in any opportunities for that.Other countries researches indicate that hand rubbing with alcohol-based solution adherence hand hygiene complioanc, regarding nurse's believes and cultural differences, this study was carried out in order to compare compliance hand hygiene with alcohol-based solution and plain soap. Material and Methods: This quasi experimental study was performed on 97 nursing personnels of Gonabad hospitals. Participants were assigned in two groups randomly. Two groups were matched, concering affecting factors. The hand hygiene behaviour was observed for 15 days. Data collected and analyzed by SPSS version 14. P-Value level less than .05 were considered. Results: Results showed that hand hygiene compliance in case and control groups in respect were %62 and %59. Although compliance with alcohol-based solution was better than soap, independent t test didn't show significant differences between two groups (p=0.625). Conclusion: however alcohol- base hand rub is resonable, time saving, easily usage and with less skin complication, perhaps the reasons of less than enough compliance are religious believes and feeling that hands arenot clean without rinsing them. Teaching the important of hand hygiene, advantages of using alcoholic solution and encouraging personnels who do hand hygiene can improve hand hygiene compliance

Keywords: Hand Hygiene Compliance, Alcohol-based solution, soap

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