Aims: For centuries, herbs have been used to avoid disease s . Peptic ulcer is a disease of any part of the stomach or intestines that exposed to acid and activated pepsin . The objective of the present research was to study the effect of Ziziphora clinopodioides aqueous extract on peptic ulcer due to acetic acid in rats.

Methods: In this experimental study, 60 Wistar rats weighing approximately 200-250g were randomly divided into 4 groups negative control , positive control, experiment 1 and experiment 2. Initially, rats were operated to give peptic ulcers by acetic acid . A day after stomach ulcer , the experimental groups received Ziziphora clinopodioides aqueous extract for 14 consecutive days and positive control received normal saline . Negative control animals received no substance . Wound healing and fibroblasts , neutrophils and macrophages per unit area were calculated after 14 days . Data was collected using the SPSS 17 software and were analyzed by one-way ANOVA and LSD tests.

Results: Wound healing in the experimental group compared to the negative control and positive control groups was significantly increased (p<0.05) . By passing time, the number of neutrophils and macrophages were increased in experimental groups and the number of fibroblasts was reduced .

Conclusion: Ziziphora clinopodioides extract is effective in the treatment of peptic ulcer induced by acetic acid.