Volume 22, Issue 1 (Winter 2016)                   Intern Med Today 2016, 22(1): 71-75 | Back to browse issues page

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Modaresi M, Arefian S. Effect of Lavender Hydro Alcoholic Extract on Liver’s Enzymes and Histology in Small Laboratory Mice. Intern Med Today 2016; 22 (1) :71-75
URL: http://imtj.gmu.ac.ir/article-1-2137-en.html
1- 1Physiology Dept, Khorasgan(Isfahan) Branch, Islamic Azad University, Isfahan, Iran , mehrdad_modaresi@hotmail.com
2- Department of Biology, Payame Noor , Isfahan , IRAN
Abstract:   (6400 Views)

Aims: In traditional medicine, lavender is known as one of the effective herbal drugs on liver function, but so far, side effects of the lavender flower extract on liver biochemistry have not been studied. The aim of this study was to find the effect of lavender hydro-alcoholic extract on liver’s tissue and enzymes.

Materials & Methods: In this experimental study, 50 mature female small mice were divided into 5 groups (each 10) control, placebo and 3 experimental groups. Placebo group received normal saline and treatment groups received the hydro-alcoholic extract of lavender in 50, 100, 200mg/kg doses 10 times every other day, interperitoneally. The levels of liver enzymes (ALT, AST and ALP) were measured and liver tissue was studied after 20 days. Data were analyzed using SPSS 16 software and variance test.

Findings: ALT enzyme was increased significantly in 200mg/kg group comparing with the control group (p<0.05). The level of AST enzyme was decreased significantly in 100- and 200mg/kg groups and the ALP amount was decreased significantly in 200mg/kg group in proportion to control group (p<0.05). In histological studies, liver tissue of 50- and 100mg/kg did not show significant pathological changes but obvious pathological changes (necrotic tissue) was observed in liver tissue of 200mg/kg group.

Conclusion: The hydro-alcoholic lavender extract causes reduction of AST and ALP enzymes in 100- and 200mg/kg doses, but the 200mg/kg dose results in severe liver tissue necrosis.

Keywords: Lavandula, Liver, Mice
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Type of Study: Original | Subject: Physiology
Received: 2015/01/17 | Accepted: 2015/11/14 | Published: 2015/11/30

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