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Background and Aim: The sedative effects of medicinal herbs of Echium Amoenum Fisch & Mey on nervous system have been known for many years. The aim of this study was to investigate the effects of methanolice extract of Echium amoenum Fisch & Mey against seizure induced by picrotoxin in mice. Materials and Methods: In this experiment study, in the first phase four groups of animals were pretreated by metabolic extract of this plant via intraperitoneal injection. After 20 minutes each animal received picrotoxin 10mg/kg for the induction of seizure. Then lateney of onset time for the beginning of seizure, duration of seizure and mortality were determined. Data were subjected to the t test and chi-square test (P<0.05). Results: The results showed that latency of seizure was increased significantly in case groups that pretreated with different doses of extract (P<0.05) (especially 6.25 mg/kg). In addition, these doses delayed significantly the time death in mice (P<0.01). Conclusion: The extract of Echium Amoenum appears to be effective on seizure induced by picrotoxin in mice.

Keywords: Echium Amoenum; Seizure; Picrotoxin; Mice

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