Volume 27, Issue 4 (Autumn 2021)
Intern Med Today 2021, 27(4): 486-501 |
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Asgharzadeh F, Hosseini M, Beheshti F, Rakhshandeh H, Mansouri S, Anaeigoudari A. Improving Effect of Ethyl Acetate Fraction of Tanacetum Parthenium Against Brain Oxidative Damage in Pentylenetetrazole-Induced Seizure Model in Mice. Intern Med Today 2021; 27 (4) :486-501
URL: http://imtj.gmu.ac.ir/article-1-3603-en.html
URL: http://imtj.gmu.ac.ir/article-1-3603-en.html
Fereshteh Asgharzadeh1 
, Mahmoud Hosseini2 , Farimah Beheshti3 , Hassan Rakhshandeh1 , Somaieh Mansouri4 , Akbar Anaeigoudari * 5
, Mahmoud Hosseini2 , Farimah Beheshti3 , Hassan Rakhshandeh1 , Somaieh Mansouri4 , Akbar Anaeigoudari * 5
1- Medicinal Plants Pharmacology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
2- Psychiatric and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
3- Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
4- Department of Anatomy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5- Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran. , anaeiga317@gmail.com
2- Psychiatric and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
3- Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
4- Department of Anatomy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5- Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran. , anaeiga317@gmail.com
Abstract: (1434 Views)
Aims: Oxidative stress plays an essential role in the pathogenesis of seizures. In this study, we investigated the effect of ethyl acetate fraction of Tanacetum parthenium against oxidative brain damage in a pentylenetetrazole(PTZ)-induced seizure model in mice.
Methods & Materials: In this experimental study, mice were divided into 6 groups: control, PTZ, and 4 other groups that, besides PTZ, received 25, 50, 100, and 200 mg/kg of the fraction. PTZ (100 mg/kg) and a fraction (30 min before PTZ) were administered intraperitoneally for 3 weeks. Delay in the onset of the minimal clonic seizure (MCS), generalized tonic-clonic seizure (GTCS), and the level of oxidative stress indexes in cortical and hippocampal tissues were measured.
Findings: Pretreatment with fraction resulted in postponing the onset seizures in the Fraction+PTZ groups compared to the PTZ group (P<0.05, P<0.01, and P<0.001). In addition, all doses of ethyl acetate fraction decreased the concentration of malondialdehyde (MDA) and increased the level of tom thiol groups and the activity of superoxide dismutase and catalase enzymes in the brain tissues compared to the PTZ group.
Conclusion: Ethyl acetate fraction of Tanacetum parthenium attenuated PTZ-stimulated seizures through improving brain tissue oxidative stress.
Methods & Materials: In this experimental study, mice were divided into 6 groups: control, PTZ, and 4 other groups that, besides PTZ, received 25, 50, 100, and 200 mg/kg of the fraction. PTZ (100 mg/kg) and a fraction (30 min before PTZ) were administered intraperitoneally for 3 weeks. Delay in the onset of the minimal clonic seizure (MCS), generalized tonic-clonic seizure (GTCS), and the level of oxidative stress indexes in cortical and hippocampal tissues were measured.
Findings: Pretreatment with fraction resulted in postponing the onset seizures in the Fraction+PTZ groups compared to the PTZ group (P<0.05, P<0.01, and P<0.001). In addition, all doses of ethyl acetate fraction decreased the concentration of malondialdehyde (MDA) and increased the level of tom thiol groups and the activity of superoxide dismutase and catalase enzymes in the brain tissues compared to the PTZ group.
Conclusion: Ethyl acetate fraction of Tanacetum parthenium attenuated PTZ-stimulated seizures through improving brain tissue oxidative stress.
Type of Study: Original |
Subject:
Physiology
Received: 2020/10/29 | Accepted: 2021/02/2 | Published: 2021/09/23
Received: 2020/10/29 | Accepted: 2021/02/2 | Published: 2021/09/23
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