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Abstract Background and Aim: Urinary tract infection (UTI) is one of the most common bacterial infections during pregnancy and it may cause important complication in mother and fetal if no treatment is conducted. This study conducted to present the most appropriate antibiotic among Cephalexin, Ampicillin, Amoxicillin and Cefixim in empirical treatment of cystitis. Materials and Methods: This study was performed in Dezyani Hospital, Gorgan University of medical sciences and private offices in 2003. It was a clinical trial that was performed on 128 pregnant women with symptomatic infection in the lower urinary tract. They were investigated in four different groups and every group had a treatment with special antibiotic. The results were compared with t and chi-square test. Results: The response rate to antibiotics was different. The highest response was due to Cephalexin (84.4%) and the lowest response was due to Ampicilline (56.3%) and there were no significant statistical differences between Amoxicillin (75%) and Cefixim (78.1%). Among patients (73.4%) had positive response to antibiotic therapy and among them، (34%) had relapse during the first month after treating. Conclusion: The results showed that the best antibiotic was Cephalexin، and the worst was Ampicillin which probably was due to high resistance of E.coli (most common pathogen) to Ampicillin. Therefore، it is recommended to use Cephalexin or Amoxicillin in empirical treatment of cystitis in pregnancy، instead of Ampicillin and Cefixim for patients with frequent relapses.

Keywords: Cystitis; Pregnant women; Treatment; Relapse

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