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Abstract: Helicobacter Pylori is well known as one of the important factors of inflammatory disease and gastro intestinal malignancies such as chronic active gastritis (type B), gastric ulcers and duodenal ulcers, gastric adenocarcinoma and mucosal associated lymphoid tissue (MALT).The epidemiology of the infection is different among developing and developed countries. This research is designed in Zahedan according to the importance of infection and different epidemiological dimensions in different areas of our country. Methods and Materials: This is a cross sectional study among 97 Zahedan health centers employees without gastrointestinal symptoms. The cases are selected by cluster random sampling design. The diagnosis was performed by ELISA test. The data was collected by the checklist including demographical characteristics. Finally, the SPSS software was used for the statistical analysis including descriptive and inference methods. Results: Total prevalence of the infections was 34 percent, 36.4 percent for male and 63.6 percent for female. There was no significant correlation between sex, age, number of family members and kind of drinking water with antibody titers. But, there was significant correlation between educational degrees and antibody titers. Conclusion: According to the results, for controlling epidemiology of antibody titers it is important that we assume the affect of the demographic factors on antibody titers. Further, according to the results and existence of the Helicobacter Pylori infection in asymptomatic persons, we advise to good control of drinking water sources and infection and increase the knowledge about hygiene. Key Words: Helicobacter Pylori, ELISA, Zahedan.

Keywords: Helicobacter Pylori, ELISA, Zahedan

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